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Virtual screening for small-molecule pathway regulators by image-profile matching.
Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan M, Gale JP, Derynck R, Turbyville T, Boerckel JD, Singh S, Kiessling LL, Schwarz TL, Varelas X, Wagner FF, Kafri R, Eisinger-Mathason TSK, Carpenter AE. Rohban MH, et al. Among authors: schwarz tl. Cell Syst. 2022 Sep 21;13(9):724-736.e9. doi: 10.1016/j.cels.2022.08.003. Epub 2022 Sep 2. Cell Syst. 2022. PMID: 36057257 Free PMC article.
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.
Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL. Harbauer AB, et al. Among authors: schwarz tl. Neuron. 2022 May 4;110(9):1516-1531.e9. doi: 10.1016/j.neuron.2022.01.035. Epub 2022 Feb 24. Neuron. 2022. PMID: 35216662 Free PMC article.
APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.
Wu CI, Vinton EA, Pearse RV 2nd, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL. Wu CI, et al. Among authors: schwarz tl. Mol Psychiatry. 2022 Apr;27(4):1970-1989. doi: 10.1038/s41380-022-01454-5. Epub 2022 Feb 23. Mol Psychiatry. 2022. PMID: 35194165 Free PMC article.
111 results