Merrett JH - Search Results

1

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.

Klumpp K, Lévêque V, Le Pogam S, Ma H, Jiang WR, Kang H, Granycome C, Singer M, Laxton C, Hang JQ, Sarma K, Smith DB, Heindl D, Hobbs CJ, Merrett JH, Symons J, Cammack N, Martin JA, Devos R, Nájera I. Klumpp K, et al. Among authors: merrett jh. J Biol Chem. 2006 Feb 17;281(7):3793-9. doi: 10.1074/jbc.M510195200. Epub 2005 Nov 29. J Biol Chem. 2006. PMID: 16316989 Free article.

2

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

Smith DB, Martin JA, Klumpp K, Baker SJ, Blomgren PA, Devos R, Granycome C, Hang J, Hobbs CJ, Jiang WR, Laxton C, Le Pogam S, Leveque V, Ma H, Maile G, Merrett JH, Pichota A, Sarma K, Smith M, Swallow S, Symons J, Vesey D, Najera I, Cammack N. Smith DB, et al. Among authors: merrett jh. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6. doi: 10.1016/j.bmcl.2007.02.004. Epub 2007 Feb 4. Bioorg Med Chem Lett. 2007. PMID: 17317178

3

Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.

Parkes KE, Ermert P, Fässler J, Ives J, Martin JA, Merrett JH, Obrecht D, Williams G, Klumpp K. Parkes KE, et al. Among authors: merrett jh. J Med Chem. 2003 Mar 27;46(7):1153-64. doi: 10.1021/jm020334u. J Med Chem. 2003. PMID: 12646026

4

A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly(A) polymerases: application to kinetic and inhibitor analysis.

Hooker L, Strong R, Adams R, Handa B, Merrett JH, Martin JA, Klumpp K. Hooker L, et al. Among authors: merrett jh. Nucleic Acids Res. 2001 Jul 1;29(13):2691-8. doi: 10.1093/nar/29.13.2691. Nucleic Acids Res. 2001. PMID: 11433013 Free PMC article.

5

The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase.

Martin JA, Thomas GJ, Merrett JH, Lambert RW, Bushnell DJ, Dunsdon SJ, Freeman AC, Hopkins RA, Johns IR, Keech E, Simmonite H, Kai-In PW, Holland M. Martin JA, et al. Among authors: merrett jh. Antivir Chem Chemother. 1998 Jan;9(1):1-8. Antivir Chem Chemother. 1998. PMID: 9875371

6

Synthesis and antiviral activity of metabolites of rimantadine.

Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Manchand PS, et al. Among authors: merrett jh. J Med Chem. 1990 Jul;33(7):1992-5. doi: 10.1021/jm00169a029. J Med Chem. 1990. PMID: 2362279

7

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1).

Martin JA, Bushnell DJ, Duncan IB, Dunsdon SJ, Hall MJ, Machin PJ, Merrett JH, Parkes KE, Roberts NA, Thomas GJ, et al. Martin JA, et al. Among authors: merrett jh. J Med Chem. 1990 Aug;33(8):2137-45. doi: 10.1021/jm00170a015. J Med Chem. 1990. PMID: 2165161

8

Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.

Martin JA, Lambert RW, Merrett JH, Parkes KE, Thomas GJ, Baker SJ, Bushnell DJ, Cansfield JE, Dunsdon SJ, Freeman AC, Hopkins RA, Johns IR, Keech E, Simmonite H, Walmsley A, Wong Kai-In P, Holland M. Martin JA, et al. Among authors: merrett jh. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1655-8. doi: 10.1016/s0960-894x(01)00256-6. Bioorg Med Chem Lett. 2001. PMID: 11425530

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