Bertotti A - Search Results

1

Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.

Bertotti A, Comoglio PM, Trusolino L. Bertotti A, et al. Cancer Res. 2005 Dec 1;65(23):10674-9. doi: 10.1158/0008-5472.CAN-05-2827. Cancer Res. 2005. PMID: 16322210

2

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.

Trusolino L, Cavassa S, Angelini P, Andó M, Bertotti A, Comoglio PM, Boccaccio C. Trusolino L, et al. Among authors: bertotti a. FASEB J. 2000 Aug;14(11):1629-40. doi: 10.1096/fj.14.11.1629. FASEB J. 2000. PMID: 10928998

3

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.

Trusolino L, Bertotti A, Comoglio PM. Trusolino L, et al. Among authors: bertotti a. Cell. 2001 Nov 30;107(5):643-54. doi: 10.1016/s0092-8674(01)00567-0. Cell. 2001. PMID: 11733063 Free article.

4

Tyrosine kinase signal specificity: lessons from the HGF receptor.

Bertotti A, Comoglio PM. Bertotti A, et al. Trends Biochem Sci. 2003 Oct;28(10):527-33. doi: 10.1016/j.tibs.2003.09.001. Trends Biochem Sci. 2003. PMID: 14559181

5

Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.

Bertotti A, Comoglio PM, Trusolino L. Bertotti A, et al. J Cell Biol. 2006 Dec 18;175(6):993-1003. doi: 10.1083/jcb.200605114. Epub 2006 Dec 11. J Cell Biol. 2006. PMID: 17158954 Free PMC article.

6

Met-driven invasive growth involves transcriptional regulation of Arhgap12.

Gentile A, D'Alessandro L, Lazzari L, Martinoglio B, Bertotti A, Mira A, Lanzetti L, Comoglio PM, Medico E. Gentile A, et al. Among authors: bertotti a. Oncogene. 2008 Sep 18;27(42):5590-8. doi: 10.1038/onc.2008.173. Epub 2008 May 26. Oncogene. 2008. PMID: 18504429 Free article.

7

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Sci Signal. 2009 Dec 8;2(100):ra80. doi: 10.1126/scisignal.2000643. Sci Signal. 2009. Corrected and republished in: Sci Signal. 2009;2(102):er11. doi: 10.1126/scisignal.2102er11 PMID: 19996456 Free article. Corrected and republished.

8

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Sci Signal. 2009;2(102):er11. doi: 10.1126/scisignal.2102er11. Sci Signal. 2009. PMID: 20039471

9

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.

Corso S, Ghiso E, Cepero V, Sierra JR, Migliore C, Bertotti A, Trusolino L, Comoglio PM, Giordano S. Corso S, et al. Among authors: bertotti a. Mol Cancer. 2010 May 26;9:121. doi: 10.1186/1476-4598-9-121. Mol Cancer. 2010. PMID: 20500904 Free PMC article.

10

Inhibition of Src impairs the growth of met-addicted gastric tumors.

Bertotti A, Bracco C, Girolami F, Torti D, Gastaldi S, Galimi F, Medico E, Elvin P, Comoglio PM, Trusolino L. Bertotti A, et al. Clin Cancer Res. 2010 Aug 1;16(15):3933-43. doi: 10.1158/1078-0432.CCR-10-0106. Epub 2010 Jul 13. Clin Cancer Res. 2010. PMID: 20628031 Free article.

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