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Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.
Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN. Schiff BA, et al. Among authors: kim s. Clin Cancer Res. 2004 Dec 15;10(24):8594-602. doi: 10.1158/1078-0432.CCR-04-0690. Clin Cancer Res. 2004. PMID: 15623643
Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model.
Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, Myers JN. Younes MN, et al. Among authors: kim s. Mol Cancer Ther. 2006 Nov;5(11):2696-705. doi: 10.1158/1535-7163.MCT-05-0228. Mol Cancer Ther. 2006. PMID: 17121916
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