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Natural and synthetic G-quadruplex interactive berberine derivatives.
Franceschin M, Rossetti L, D'Ambrosio A, Schirripa S, Bianco A, Ortaggi G, Savino M, Schultes C, Neidle S. Franceschin M, et al. Among authors: ortaggi g. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1707-11. doi: 10.1016/j.bmcl.2005.12.001. Epub 2006 Jan 11. Bioorg Med Chem Lett. 2006. PMID: 16377184
The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase.
Franceschin M, Lombardo CM, Pascucci E, D'Ambrosio D, Micheli E, Bianco A, Ortaggi G, Savino M. Franceschin M, et al. Among authors: ortaggi g. Bioorg Med Chem. 2008 Mar 1;16(5):2292-304. doi: 10.1016/j.bmc.2007.11.065. Epub 2007 Nov 29. Bioorg Med Chem. 2008. PMID: 18165014
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: ortaggi g. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.
Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A, Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, Biroccio A. Franceschin M, et al. Among authors: ortaggi g. ChemMedChem. 2012 Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. ChemMedChem. 2012. PMID: 23097341
29 results