Chu V - Search Results

1

Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor.

Paccaly A, Ozoux ML, Chu V, Simcox K, Marks V, Freyburger G, Sibille M, Shukla U. Paccaly A, et al. Among authors: chu v. Thromb Haemost. 2005 Dec;94(6):1156-63. doi: 10.1160/TH05-05-0347. Thromb Haemost. 2005. PMID: 16411387 Clinical Trial.

2

Pharmacokinetic/pharmacodynamic relationships for otamixaban, a direct factor Xa inhibitor, in healthy subjects.

Paccaly A, Frick A, Ozoux ML, Chu V, Rosenburg R, Hinder M, Shukla U, Jensen BK. Paccaly A, et al. Among authors: chu v. J Clin Pharmacol. 2006 Jan;46(1):45-51. doi: 10.1177/0091270005281818. J Clin Pharmacol. 2006. PMID: 16397283 Clinical Trial.

3

Pharmacological characterization of a novel factor Xa inhibitor, FXV673.

Chu V, Brown K, Colussi D, Gao J, Bostwick J, Kasiewski C, Bentley R, Morgan S, Guertin K, Pauls HW, Gong Y, Zulli A, Perrone MH, Dunwiddie CT, Leadley RJ. Chu V, et al. Thromb Res. 2001 Aug 15;103(4):309-24. doi: 10.1016/s0049-3848(01)00328-0. Thromb Res. 2001. PMID: 11562341

4

In vitro characterization of a novel factor Xa inhibitor, RPR 130737.

Chu V, Brown K, Colussi D, Choi YM, Green D, Pauls HW, Spada AP, Perrone MH, Leadley RJ Jr, Dunwiddie CT. Chu V, et al. Thromb Res. 2000 Jul 1;99(1):71-82. doi: 10.1016/s0049-3848(00)00227-9. Thromb Res. 2000. PMID: 11012377

5

RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit.

Bostwick JS, Bentley R, Morgan S, Brown K, Chu V, Ewing WR, Spada AP, Pauls H, Perrone MH, Dunwiddie CT, Leadley RJ Jr. Bostwick JS, et al. Among authors: chu v. Thromb Haemost. 1999 Jan;81(1):157-60. Thromb Haemost. 1999. PMID: 10348709

6

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.

Guertin KR, Gardner CJ, Klein SI, Zulli AL, Czekaj M, Gong Y, Spada AP, Cheney DL, Maignan S, Guilloteau JP, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Dunwiddie CT, Leadley RJ, Pauls HW. Guertin KR, et al. Among authors: chu v. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4. doi: 10.1016/s0960-894x(02)00213-5. Bioorg Med Chem Lett. 2002. PMID: 12039587

7

Role of short-term inhibition of factor Xa by FXV673 in arterial passivation: a study in a chronic model of thrombosis in conscious dogs.

Rebello SS, Kasiewski CJ, Wang W, Bentley RG, Morgan SR, Chu V, Colussi D, Brown K, Perrone MH, Leadley RJ. Rebello SS, et al. Among authors: chu v. J Cardiovasc Pharmacol. 2001 Aug;38(2):288-97. doi: 10.1097/00005344-200108000-00015. J Cardiovasc Pharmacol. 2001. PMID: 11483879

8

Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombolysis.

Rebello SS, Bentley RG, Morgan SR, Kasiewski CJ, Chu V, Perrone MH, Leadley RJ. Rebello SS, et al. Among authors: chu v. Br J Pharmacol. 2001 Aug;133(7):1190-8. doi: 10.1038/sj.bjp.0704182. Br J Pharmacol. 2001. PMID: 11487531 Free PMC article.

9

Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.

He W, Hanney B, Myers MR, Condon S, Becker MR, Spada AP, Burns C, Brown K, Colussi D, Chu V. He W, et al. Among authors: chu v. Bioorg Med Chem Lett. 2002 Mar 25;12(6):919-22. doi: 10.1016/s0960-894x(02)00056-2. Bioorg Med Chem Lett. 2002. PMID: 11958994

10

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency.

Czekaj M, Klein SI, Guertin KR, Gardner CJ, Zulli AL, Pauls HW, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Leadley RJ, Dunwiddie CT. Czekaj M, et al. Among authors: chu v. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1667-70. doi: 10.1016/s0960-894x(02)00212-3. Bioorg Med Chem Lett. 2002. PMID: 12039586

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