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P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. Vanhaesebroeck B, et al. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4330-5. doi: 10.1073/pnas.94.9.4330. Proc Natl Acad Sci U S A. 1997. PMID: 9113989 Free PMC article.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.
Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B. Geering B, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7809-14. doi: 10.1073/pnas.0700373104. Epub 2007 Apr 30. Proc Natl Acad Sci U S A. 2007. PMID: 17470792 Free PMC article.
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. Guillermet-Guibert J, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. doi: 10.1073/pnas.0707761105. Epub 2008 Jun 10. Proc Natl Acad Sci U S A. 2008. PMID: 18544649 Free PMC article.
PI3K: from the bench to the clinic and back.
Vanhaesebroeck B, Vogt PK, Rommel C. Vanhaesebroeck B, et al. Curr Top Microbiol Immunol. 2010;347:1-19. doi: 10.1007/82_2010_65. Curr Top Microbiol Immunol. 2010. PMID: 20549473 Free PMC article. Review.
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.
Madsen RR, Knox RG, Pearce W, Lopez S, Mahler-Araujo B, McGranahan N, Vanhaesebroeck B, Semple RK. Madsen RR, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8380-8389. doi: 10.1073/pnas.1821093116. Epub 2019 Apr 4. Proc Natl Acad Sci U S A. 2019. PMID: 30948643 Free PMC article.
220 results