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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Cai D, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. doi: 10.1073/pnas.0510710103. Epub 2006 Jan 31. Proc Natl Acad Sci U S A. 2006. PMID: 16449385 Free PMC article.
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Cai D, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1941-6. doi: 10.1073/pnas.0510708103. Epub 2006 Jan 31. Proc Natl Acad Sci U S A. 2006. PMID: 16449386 Free PMC article.
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.
Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M. Bettayeb K, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5412-7. doi: 10.1073/pnas.1604156113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114525 Free PMC article.
Bidirectional regulation of Aβ levels by Presenilin 1.
Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P. Bustos V, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533411 Free PMC article.
Chaperones increase association of tau protein with microtubules.
Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H. Dou F, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):721-6. doi: 10.1073/pnas.242720499. Epub 2003 Jan 9. Proc Natl Acad Sci U S A. 2003. PMID: 12522269 Free PMC article.
Gleevec inhibits beta-amyloid production but not Notch cleavage.
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Netzer WJ, et al. Among authors: greengard p. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12444-9. doi: 10.1073/pnas.1534745100. Epub 2003 Oct 1. Proc Natl Acad Sci U S A. 2003. PMID: 14523244 Free PMC article.
950 results