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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Cai D, et al. Among authors: sisodia ss. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. doi: 10.1073/pnas.0510710103. Epub 2006 Jan 31. Proc Natl Acad Sci U S A. 2006. PMID: 16449385 Free PMC article.
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Cai D, et al. Among authors: sisodia ss. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1941-6. doi: 10.1073/pnas.0510708103. Epub 2006 Jan 31. Proc Natl Acad Sci U S A. 2006. PMID: 16449386 Free PMC article.
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Seeger M, et al. Among authors: sisodia ss. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5090-4. doi: 10.1073/pnas.94.10.5090. Proc Natl Acad Sci U S A. 1997. PMID: 9144195 Free PMC article.
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Xu H, et al. Among authors: sisodia ss. Nat Med. 1998 Apr;4(4):447-51. doi: 10.1038/nm0498-447. Nat Med. 1998. PMID: 9546791
Activation and intrinsic gamma-secretase activity of presenilin 1.
Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Ahn K, et al. Among authors: sisodia ss. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21435-40. doi: 10.1073/pnas.1013246107. Epub 2010 Nov 29. Proc Natl Acad Sci U S A. 2010. PMID: 21115843 Free PMC article.
234 results