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MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene.
Storlazzi CT, Fioretos T, Surace C, Lonoce A, Mastrorilli A, Strömbeck B, D'Addabbo P, Iacovelli F, Minervini C, Aventin A, Dastugue N, Fonatsch C, Hagemeijer A, Jotterand M, Mühlematter D, Lafage-Pochitaloff M, Nguyen-Khac F, Schoch C, Slovak ML, Smith A, Solè F, Van Roy N, Johansson B, Rocchi M. Storlazzi CT, et al. Among authors: hagemeijer a. Hum Mol Genet. 2006 Mar 15;15(6):933-42. doi: 10.1093/hmg/ddl010. Epub 2006 Feb 1. Hum Mol Genet. 2006. PMID: 16452126
The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats.
Barbouti A, Stankiewicz P, Nusbaum C, Cuomo C, Cook A, Höglund M, Johansson B, Hagemeijer A, Park SS, Mitelman F, Lupski JR, Fioretos T. Barbouti A, et al. Among authors: hagemeijer a. Am J Hum Genet. 2004 Jan;74(1):1-10. doi: 10.1086/380648. Epub 2003 Dec 8. Am J Hum Genet. 2004. PMID: 14666446 Free PMC article.
Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies.
Poppe B, Vandesompele J, Schoch C, Lindvall C, Mrozek K, Bloomfield CD, Beverloo HB, Michaux L, Dastugue N, Herens C, Yigit N, De Paepe A, Hagemeijer A, Speleman F. Poppe B, et al. Among authors: hagemeijer a. Blood. 2004 Jan 1;103(1):229-35. doi: 10.1182/blood-2003-06-2163. Epub 2003 Aug 28. Blood. 2004. PMID: 12946992 Free article.
Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations.
Fioretos T, Strömbeck B, Sandberg T, Johansson B, Billström R, Borg A, Nilsson PG, Van Den Berghe H, Hagemeijer A, Mitelman F, Höglund M. Fioretos T, et al. Among authors: hagemeijer a. Blood. 1999 Jul 1;94(1):225-32. Blood. 1999. PMID: 10381517 Free article.
Systematic screening at diagnosis of -5/del(5)(q31), -7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high-risk myelodysplastic syndrome patients: concordances and discrepancies with conventional cytogenetics.
Beyer V, Castagné C, Mühlematter D, Parlier V, Gmür J, Hess U, Kovacsovics T, Meyer-Monard S, Tichelli A, Tobler A, Jacky E, Schanz U, Bargetzi M, Hagemeijer A, de Witte T, van Melle G, Jotterand M. Beyer V, et al. Among authors: hagemeijer a. Cancer Genet Cytogenet. 2004 Jul 1;152(1):29-41. doi: 10.1016/j.cancergencyto.2003.10.005. Cancer Genet Cytogenet. 2004. PMID: 15193439
EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22.
De Weer A, Speleman F, Cauwelier B, Van Roy N, Yigit N, Verhasselt B, De Moerloose B, Benoit Y, Noens L, Selleslag D, Lippert E, Struski S, Bastard C, De Paepe A, Vandenberghe P, Hagemeijer A, Dastugue N, Poppe B; Groupe Français de Cytogénétique Hématologique (GFCH). De Weer A, et al. Among authors: hagemeijer a. Haematologica. 2008 Dec;93(12):1903-7. doi: 10.3324/haematol.13192. Epub 2008 Sep 24. Haematologica. 2008. PMID: 18815193 Free article.
372 results