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Page 1
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.
Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Che J, Lee CC, Caldwell J, Kanazawa T, Umemura I, Matsuura N, Ohmori O, Honda T, Gray N, He Y. Choi HS, et al. Among authors: karanewsky d. Bioorg Med Chem Lett. 2006 May 15;16(10):2689-92. doi: 10.1016/j.bmcl.2006.02.032. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16524731
Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
Wu B, Kuhen K, Ngoc Nguyen T, Ellis D, Anaclerio B, He X, Yang K, Karanewsky D, Yin H, Wolff K, Bieza K, Caldwell J, He Y. Wu B, et al. Among authors: karanewsky d. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3430-3. doi: 10.1016/j.bmcl.2006.04.012. Epub 2006 Apr 24. Bioorg Med Chem Lett. 2006. PMID: 16632349
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors.
Huang S, Liu Z, Tian SS, Sandberg M, Spalding TA, Romeo R, Iskandar M, Wang Z, Karanewsky D, He Y. Huang S, et al. Among authors: karanewsky d. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2324-8. doi: 10.1016/j.bmcl.2008.02.079. Epub 2008 Mar 6. Bioorg Med Chem Lett. 2008. PMID: 18353642
Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I.
Zhang G, Ren P, Gray NS, Sim T, Liu Y, Wang X, Che J, Tian SS, Sandberg ML, Spalding TA, Romeo R, Iskandar M, Chow D, Martin Seidel H, Karanewsky DS, He Y. Zhang G, et al. Among authors: karanewsky ds. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5618-21. doi: 10.1016/j.bmcl.2008.08.104. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18793846
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Zhang G, Ren P, Gray NS, Sim T, Wang X, Liu Y, Che J, Dong W, Tian SS, Sandberg ML, Spalding TA, Romeo R, Iskandar M, Wang Z, Seidel HM, Karanewsky DS, He Y. Zhang G, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6691-5. doi: 10.1016/j.bmcl.2009.09.123. Epub 2009 Oct 12. Bioorg Med Chem Lett. 2009. PMID: 19854052
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
Marsilje TH, Pei W, Chen B, Lu W, Uno T, Jin Y, Jiang T, Kim S, Li N, Warmuth M, Sarkisova Y, Sun F, Steffy A, Pferdekamper AC, Li AG, Joseph SB, Kim Y, Liu B, Tuntland T, Cui X, Gray NS, Steensma R, Wan Y, Jiang J, Chopiuk G, Li J, Gordon WP, Richmond W, Johnson K, Chang J, Groessl T, He YQ, Phimister A, Aycinena A, Lee CC, Bursulaya B, Karanewsky DS, Seidel HM, Harris JL, Michellys PY. Marsilje TH, et al. J Med Chem. 2013 Jul 25;56(14):5675-90. doi: 10.1021/jm400402q. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23742252
69 results