Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.
Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N.
Lu SC, et al. Among authors: kuhlenkamp j.
J Clin Invest. 1992 Aug;90(2):524-32. doi: 10.1172/JCI115890.
J Clin Invest. 1992.
PMID: 1353765
Free PMC article.
We reported that glucagon and phenylephrine decrease hepatocyte GSH by inhibiting gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu, S.C., J. Kuhlenkamp, C. Garcia-Ruiz, and N. Kaplowitz. 1991. J. Clin. Invest. 88:260-269) …
We reported that glucagon and phenylephrine decrease hepatocyte GSH by inhibiting gamma-glutamylcysteine synthetase (GCS), the rate-limiting …