Kotti TJ - Search Results

1

Brain cholesterol turnover required for geranylgeraniol production and learning in mice.

Kotti TJ, Ramirez DM, Pfeiffer BE, Huber KM, Russell DW. Kotti TJ, et al. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3869-74. doi: 10.1073/pnas.0600316103. Epub 2006 Feb 27. Proc Natl Acad Sci U S A. 2006. PMID: 16505352 Free PMC article.

2

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.

Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, Russell DW. Lund EG, et al. J Biol Chem. 2003 Jun 20;278(25):22980-8. doi: 10.1074/jbc.M303415200. Epub 2003 Apr 9. J Biol Chem. 2003. PMID: 12686551 Free article.

3

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.

Kotti T, Head DD, McKenna CE, Russell DW. Kotti T, et al. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11394-9. doi: 10.1073/pnas.0805556105. Epub 2008 Aug 6. Proc Natl Acad Sci U S A. 2008. PMID: 18685105 Free PMC article.

4

Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.

Russell DW, Halford RW, Ramirez DM, Shah R, Kotti T. Russell DW, et al. Annu Rev Biochem. 2009;78:1017-40. doi: 10.1146/annurev.biochem.78.072407.103859. Annu Rev Biochem. 2009. PMID: 19489738 Free PMC article. Review.

5

Reelin protects against amyloid β toxicity in vivo.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J. Lane-Donovan C, et al. Sci Signal. 2015 Jul 7;8(384):ra67. doi: 10.1126/scisignal.aaa6674. Sci Signal. 2015. PMID: 26152694 Free PMC article.

6

Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Pieper AA, et al. Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018. Cell. 2010. PMID: 20603013 Free PMC article.

7

In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes.

Kotti TJ, Savolainen K, Helander HM, Yagi A, Novikov DK, Kalkkinen N, Conzelmann E, Hiltunen JK, Schmitz W. Kotti TJ, et al. J Biol Chem. 2000 Jul 7;275(27):20887-95. doi: 10.1074/jbc.M002067200. J Biol Chem. 2000. PMID: 10770938 Free article.

8

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.

Savolainen K, Bhaumik P, Schmitz W, Kotti TJ, Conzelmann E, Wierenga RK, Hiltunen JK. Savolainen K, et al. Among authors: kotti tj. J Biol Chem. 2005 Apr 1;280(13):12611-20. doi: 10.1074/jbc.M409704200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632186 Free article.

9

A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.

Savolainen K, Kotti TJ, Schmitz W, Savolainen TI, Sormunen RT, Ilves M, Vainio SJ, Conzelmann E, Hiltunen JK. Savolainen K, et al. Among authors: kotti tj. Hum Mol Genet. 2004 May 1;13(9):955-65. doi: 10.1093/hmg/ddh107. Epub 2004 Mar 11. Hum Mol Genet. 2004. PMID: 15016763

10

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist AP, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ. Selkälä EM, et al. Among authors: kotti tj. Biochim Biophys Acta. 2013 Aug;1831(8):1335-43. doi: 10.1016/j.bbalip.2013.05.002. Epub 2013 May 13. Biochim Biophys Acta. 2013. PMID: 23680781

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