Valine 114 replacements in archaeal elongation factor 1 alpha enhanced its ability to interact with aminoacyl-tRNA and kirromycin.
Masullo M, Cantiello P, De Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P.
Masullo M, et al. Among authors: arcari p.
Biochemistry. 2002 Dec 10;41(49):14482-8. doi: 10.1021/bi026428n.
Biochemistry. 2002.
PMID: 12463746
Interestingly, the decreased intrinsic GTPase activity of V114E was partially restored by kirromycin, an effect already observed for the G13A mutant of SsEF-1alpha [Masullo, M., Cantiello, P., de Paola, B., Catanzano, F., Arcari, P., and Bocchini, V. (2002) B …
Interestingly, the decreased intrinsic GTPase activity of V114E was partially restored by kirromycin, an effect already observed for the G13 …