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Deletions of 17p13.1 and 13q14 are uncommon in Waldenström macroglobulinemia clonal cells and mostly seen at the time of disease progression.
Schop RF, Jalal SM, Van Wier SA, Ahmann GJ, Bailey RJ, Kyle RA, Greipp PR, Rajkumar SV, Gertz MA, Lust JA, Lacy MQ, Dispenzieri A, Witzig TE, Fonseca R. Schop RF, et al. Among authors: jalal sm. Cancer Genet Cytogenet. 2002 Jan 1;132(1):55-60. doi: 10.1016/s0165-4608(01)00526-x. Cancer Genet Cytogenet. 2002. PMID: 11801310
A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS.
Chng WJ, Van Wier SA, Ahmann GJ, Winkler JM, Jalal SM, Bergsagel PL, Chesi M, Trendle MC, Oken MM, Blood E, Henderson K, Santana-Dávila R, Kyle RA, Gertz MA, Lacy MQ, Dispenzieri A, Greipp PR, Fonseca R. Chng WJ, et al. Among authors: jalal sm. Blood. 2005 Sep 15;106(6):2156-61. doi: 10.1182/blood-2005-02-0761. Epub 2005 May 26. Blood. 2005. PMID: 15920009 Free PMC article.
Ploidy status rarely changes in myeloma patients at disease progression.
Chng WJ, Winkler JM, Greipp PR, Jalal SM, Bergsagel PL, Chesi M, Trendle MC, Ahmann GJ, Henderson K, Blood E, Oken MM, Hulbert A, Van Wier SA, Santana-Dávila R, Kyle RA, Gertz MA, Lacy MQ, Dispenzieri A, Fonseca R. Chng WJ, et al. Among authors: jalal sm. Leuk Res. 2006 Mar;30(3):266-71. doi: 10.1016/j.leukres.2005.07.004. Epub 2005 Aug 18. Leuk Res. 2006. PMID: 16111750 Clinical Trial.
123 results