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Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis.
Palmer S, Kearney M, Maldarelli F, Halvas EK, Bixby CJ, Bazmi H, Rock D, Falloon J, Davey RT Jr, Dewar RL, Metcalf JA, Hammer S, Mellors JW, Coffin JM. Palmer S, et al. Among authors: metcalf ja. J Clin Microbiol. 2005 Jan;43(1):406-13. doi: 10.1128/JCM.43.1.406-413.2005. J Clin Microbiol. 2005. PMID: 15635002 Free PMC article.
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.
Maldarelli F, Palmer S, King MS, Wiegand A, Polis MA, Mican J, Kovacs JA, Davey RT, Rock-Kress D, Dewar R, Liu S, Metcalf JA, Rehm C, Brun SC, Hanna GJ, Kempf DJ, Coffin JM, Mellors JW. Maldarelli F, et al. Among authors: metcalf ja. PLoS Pathog. 2007 Apr;3(4):e46. doi: 10.1371/journal.ppat.0030046. PLoS Pathog. 2007. PMID: 17411338 Free PMC article. Clinical Trial.
A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection.
Dybul M, Nies-Kraske E, Dewar R, Maldarelli F, Hallahan CW, Daucher M, Piscitelli SC, Ehler L, Weigand A, Palmer S, Metcalf JA, Davey RT, Rock Kress DM, Powers A, Beck I, Frenkel L, Baseler M, Coffin J, Fauci AS. Dybul M, et al. Among authors: metcalf ja. J Infect Dis. 2004 Jun 1;189(11):1974-82. doi: 10.1086/386344. Epub 2004 May 10. J Infect Dis. 2004. PMID: 15143462 Clinical Trial.
HIV populations are large and accumulate high genetic diversity in a nonlinear fashion.
Maldarelli F, Kearney M, Palmer S, Stephens R, Mican J, Polis MA, Davey RT, Kovacs J, Shao W, Rock-Kress D, Metcalf JA, Rehm C, Greer SE, Lucey DL, Danley K, Alter H, Mellors JW, Coffin JM. Maldarelli F, et al. Among authors: metcalf ja. J Virol. 2013 Sep;87(18):10313-23. doi: 10.1128/JVI.01225-12. Epub 2013 May 15. J Virol. 2013. PMID: 23678164 Free PMC article.
Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness.
Brann TW, Dewar RL, Jiang MK, Shah A, Nagashima K, Metcalf JA, Falloon J, Lane HC, Imamichi T. Brann TW, et al. Among authors: metcalf ja. J Virol. 2006 Jun;80(12):6136-45. doi: 10.1128/JVI.02212-05. J Virol. 2006. PMID: 16731952 Free PMC article.
Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy.
Nies-Kraske E, Schacker TW, Condoluci D, Orenstein J, Brenchley J, Fox C, Daucher M, Dewar R, Urban E, Hill B, Guenaga J, Hoover S, Maldarelli F, Hallahan CW, Horn J, Kottilil S, Chun TW, Folino M, Palmer S, Wiegand A, O'Shea MA, Metcalf JA, Douek DC, Coffin J, Haase A, Fauci AS, Dybul M. Nies-Kraske E, et al. Among authors: metcalf ja. J Infect Dis. 2009 Jun 1;199(11):1648-56. doi: 10.1086/598980. J Infect Dis. 2009. PMID: 19432547 Free PMC article.
191 results