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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE. Boeddrich A, et al. Among authors: schugardt n. EMBO J. 2006 Apr 5;25(7):1547-58. doi: 10.1038/sj.emboj.7601043. Epub 2006 Mar 9. EMBO J. 2006. PMID: 16525503 Free PMC article.
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser V, Engemann S, Bröcker W, Dunkel I, Boeddrich A, Waelter S, Nordhoff E, Lurz R, Schugardt N, Rautenberg S, Herhaus C, Barnickel G, Böttcher H, Lehrach H, Wanker EE. Heiser V, et al. Among authors: schugardt n. Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4(Suppl 4):16400-6. doi: 10.1073/pnas.182426599. Epub 2002 Aug 28. Proc Natl Acad Sci U S A. 2002. PMID: 12200548 Free PMC article.