Kazantsev AG - Search Results

1

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Bodner RA, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. doi: 10.1073/pnas.0511256103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537516 Free PMC article.

2

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.

Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. Zhang X, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7. doi: 10.1073/pnas.0408936102. Epub 2005 Jan 10. Proc Natl Acad Sci U S A. 2005. PMID: 15642944 Free PMC article.

3

New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions.

Bodner RA, Housman DE, Kazantsev AG. Bodner RA, et al. Among authors: kazantsev ag. Cell Cycle. 2006 Jul;5(14):1477-80. doi: 10.4161/cc.5.14.2929. Epub 2006 Jul 17. Cell Cycle. 2006. PMID: 16861893 Review.

4

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. Chopra V, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. doi: 10.1073/pnas.0707842104. Epub 2007 Oct 9. Proc Natl Acad Sci U S A. 2007. PMID: 17925440 Free PMC article.

5

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.

Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH Jr. Maxwell MM, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3178-83. doi: 10.1073/pnas.0308726100. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981234 Free PMC article.

6

Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.

Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG. Coufal M, et al. Among authors: kazantsev ag. J Biomol Screen. 2007 Apr;12(3):351-60. doi: 10.1177/1087057107299428. Epub 2007 Mar 22. J Biomol Screen. 2007. PMID: 17379859

7

Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.

Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG. Outeiro TF, et al. Among authors: kazantsev ag. Biochem Biophys Res Commun. 2007 Jun 8;357(3):596-602. doi: 10.1016/j.bbrc.2007.03.163. Epub 2007 Apr 5. Biochem Biophys Res Commun. 2007. PMID: 17449015

8

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Outeiro TF, et al. Among authors: kazantsev ag. Science. 2007 Jul 27;317(5837):516-9. doi: 10.1126/science.1143780. Epub 2007 Jun 21. Science. 2007. PMID: 17588900

9

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. Kazantsev A, et al. Nat Genet. 2002 Apr;30(4):367-76. doi: 10.1038/ng864. Epub 2002 Mar 25. Nat Genet. 2002. PMID: 11925563

10

Evidence for a recruitment and sequestration mechanism in Huntington's disease.

Preisinger E, Jordan BM, Kazantsev A, Housman D. Preisinger E, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1029-34. doi: 10.1098/rstb.1999.0455. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434302 Free PMC article.

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