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Page 1
Chaperoning of glucocorticoid receptors.
Pratt WB, Morishima Y, Murphy M, Harrell M. Pratt WB, et al. Among authors: morishima y. Handb Exp Pharmacol. 2006;(172):111-38. doi: 10.1007/3-540-29717-0_5. Handb Exp Pharmacol. 2006. PMID: 16610357 Review.
Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket.
Morishima Y, Murphy PJ, Li DP, Sanchez ER, Pratt WB. Morishima Y, et al. J Biol Chem. 2000 Jun 16;275(24):18054-60. doi: 10.1074/jbc.M000434200. J Biol Chem. 2000. PMID: 10764743 Free article.
Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and three proteins, Hop, hsp40, p23, act as co-chaperones that enhance activation and assembly (Morishima, Y., Kanelakis, K. C., Silve …
Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and thre …
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.
Kanelakis KC, Murphy PJ, Galigniana MD, Morishima Y, Takayama S, Reed JC, Toft DO, Pratt WB. Kanelakis KC, et al. Among authors: morishima y. Biochemistry. 2000 Nov 21;39(46):14314-21. doi: 10.1021/bi001671c. Biochemistry. 2000. PMID: 11087380
Using purified proteins, we have prepared a five-protein heterocomplex assembly system consisting of two proteins essential for heterocomplex assembly-hsp90 and hsp70-and three proteins that act as co-chaperones to enhance assembly-Hop, hsp40, p23 [Morishima, Y., Ka …
Using purified proteins, we have prepared a five-protein heterocomplex assembly system consisting of two proteins essential for heterocomple …
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes.
Morishima Y, Kanelakis KC, Murphy PJ, Shewach DS, Pratt WB. Morishima Y, et al. Biochemistry. 2001 Jan 30;40(4):1109-16. doi: 10.1021/bi002399+. Biochemistry. 2001. PMID: 11170435
The first event in assembly is the ATP-dependent and hsp40 (YDJ-1)-dependent binding of hsp70 to the GR, which primes the receptor for subsequent ATP-dependent activation by hsp90 [Morishima, Y., Murphy, P. J. M., Li, D. P., Sanchez, E. R., and Pratt, W. B. (2000) J …
The first event in assembly is the ATP-dependent and hsp40 (YDJ-1)-dependent binding of hsp70 to the GR, which primes the receptor for subse …
919 results