Copeland RA - Search Results

1

An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.

Luo L, Pappalardi MB, Tummino PJ, Copeland RA, Fraser ME, Grzyska PK, Hausinger RP. Luo L, et al. Among authors: copeland ra. Anal Biochem. 2006 Jun 1;353(1):69-74. doi: 10.1016/j.ab.2006.03.033. Epub 2006 Apr 19. Anal Biochem. 2006. PMID: 16643838

2

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.

Pappalardi MB, Martin JD, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Lor L, Schwartz B, Duffy K, Gontarek R, Tummino PJ, Copeland RA, Luo L. Pappalardi MB, et al. Among authors: copeland ra. Biochemistry. 2008 Oct 28;47(43):11165-7. doi: 10.1021/bi801624f. Epub 2008 Oct 4. Biochemistry. 2008. PMID: 18834144

3

A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies.

Copeland RA, Luo L, Auger KR, Huang PS. Copeland RA, et al. Anal Biochem. 2005 Feb 15;337(2):351-3. doi: 10.1016/j.ab.2004.10.010. Anal Biochem. 2005. PMID: 15691518 No abstract available.

4

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.

Ma J, Martin JD, Zhang H, Auger KR, Ho TF, Kirkpatrick RB, Grooms MH, Johanson KO, Tummino PJ, Copeland RA, Lai Z. Ma J, et al. Among authors: copeland ra. Biochemistry. 2006 Aug 1;45(30):9238-45. doi: 10.1021/bi060661u. Biochemistry. 2006. PMID: 16866370

5

Binding of TPX2 to Aurora A alters substrate and inhibitor interactions.

Anderson K, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Patrick D, Silva D, Tummino PJ, Copeland RA, Lai Z. Anderson K, et al. Among authors: copeland ra. Biochemistry. 2007 Sep 11;46(36):10287-95. doi: 10.1021/bi7011355. Epub 2007 Aug 18. Biochemistry. 2007. PMID: 17705509

6

Residence time of receptor-ligand complexes and its effect on biological function.

Tummino PJ, Copeland RA. Tummino PJ, et al. Among authors: copeland ra. Biochemistry. 2008 May 20;47(20):5481-92. doi: 10.1021/bi8002023. Epub 2008 Apr 16. Biochemistry. 2008. PMID: 18412369 Review.

7

Targeting enzyme inhibitors in drug discovery.

Copeland RA, Harpel MR, Tummino PJ. Copeland RA, et al. Expert Opin Ther Targets. 2007 Jul;11(7):967-78. doi: 10.1517/14728222.11.7.967. Expert Opin Ther Targets. 2007. PMID: 17614764

8

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L. Pappalardi MB, et al. Among authors: copeland ra. Biochem J. 2011 Jun 1;436(2):363-9. doi: 10.1042/BJ20101201. Biochem J. 2011. PMID: 21410436

9

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.

Luo L, Carson JD, Dhanak D, Jackson JR, Huang PS, Lee Y, Sakowicz R, Copeland RA. Luo L, et al. Among authors: copeland ra. Biochemistry. 2004 Dec 7;43(48):15258-66. doi: 10.1021/bi048282t. Biochemistry. 2004. PMID: 15568818

10

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.

Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, Dhanak D, Copeland RA, Gontarek RR, Tummino PJ, Luo L. Carson JD, et al. Among authors: copeland ra. Biochem J. 2008 Jan 15;409(2):519-24. doi: 10.1042/BJ20070681. Biochem J. 2008. PMID: 17877460

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