Tummino PJ - Search Results

1

An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.

Luo L, Pappalardi MB, Tummino PJ, Copeland RA, Fraser ME, Grzyska PK, Hausinger RP. Luo L, et al. Among authors: tummino pj. Anal Biochem. 2006 Jun 1;353(1):69-74. doi: 10.1016/j.ab.2006.03.033. Epub 2006 Apr 19. Anal Biochem. 2006. PMID: 16643838

2

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.

Pappalardi MB, Martin JD, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Lor L, Schwartz B, Duffy K, Gontarek R, Tummino PJ, Copeland RA, Luo L. Pappalardi MB, et al. Among authors: tummino pj. Biochemistry. 2008 Oct 28;47(43):11165-7. doi: 10.1021/bi801624f. Epub 2008 Oct 4. Biochemistry. 2008. PMID: 18834144

3

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.

Ma J, Martin JD, Zhang H, Auger KR, Ho TF, Kirkpatrick RB, Grooms MH, Johanson KO, Tummino PJ, Copeland RA, Lai Z. Ma J, et al. Among authors: tummino pj. Biochemistry. 2006 Aug 1;45(30):9238-45. doi: 10.1021/bi060661u. Biochemistry. 2006. PMID: 16866370

4

Binding of TPX2 to Aurora A alters substrate and inhibitor interactions.

Anderson K, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Patrick D, Silva D, Tummino PJ, Copeland RA, Lai Z. Anderson K, et al. Among authors: tummino pj. Biochemistry. 2007 Sep 11;46(36):10287-95. doi: 10.1021/bi7011355. Epub 2007 Aug 18. Biochemistry. 2007. PMID: 17705509

5

Residence time of receptor-ligand complexes and its effect on biological function.

Tummino PJ, Copeland RA. Tummino PJ, et al. Biochemistry. 2008 May 20;47(20):5481-92. doi: 10.1021/bi8002023. Epub 2008 Apr 16. Biochemistry. 2008. PMID: 18412369 Review.

6

Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.

Van Aller GS, Carson JD, Fernandes C, Lehr R, Sinnamon RH, Kirkpatrick RB, Tummino PJ, Luo L. Van Aller GS, et al. Among authors: tummino pj. Anal Biochem. 2008 Dec 15;383(2):311-5. doi: 10.1016/j.ab.2008.08.037. Epub 2008 Sep 10. Anal Biochem. 2008. PMID: 18814837

7

Targeting enzyme inhibitors in drug discovery.

Copeland RA, Harpel MR, Tummino PJ. Copeland RA, et al. Among authors: tummino pj. Expert Opin Ther Targets. 2007 Jul;11(7):967-78. doi: 10.1517/14728222.11.7.967. Expert Opin Ther Targets. 2007. PMID: 17614764

8

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L. Pappalardi MB, et al. Among authors: tummino pj. Biochem J. 2011 Jun 1;436(2):363-9. doi: 10.1042/BJ20101201. Biochem J. 2011. PMID: 21410436

9

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.

Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, Dhanak D, Copeland RA, Gontarek RR, Tummino PJ, Luo L. Carson JD, et al. Among authors: tummino pj. Biochem J. 2008 Jan 15;409(2):519-24. doi: 10.1042/BJ20070681. Biochem J. 2008. PMID: 17877460

10

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.

Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA. Luo L, et al. Among authors: tummino pj. J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21. J Am Chem Soc. 2008. PMID: 18491908

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