Dent P - Search Results

1

The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.

Gao N, Kramer L, Rahmani M, Dent P, Grant S. Gao N, et al. Among authors: dent p. Mol Pharmacol. 2006 Aug;70(2):645-55. doi: 10.1124/mol.106.024505. Epub 2006 May 3. Mol Pharmacol. 2006. PMID: 16672643

2

Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.

Dai Y, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Cell Cycle. 2002 Mar-Apr;1(2):143-52. Cell Cycle. 2002. PMID: 12429924

3

Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.

Wang S, Wang Z, Dent P, Grant S. Wang S, et al. Among authors: dent p. Blood. 2003 May 1;101(9):3648-57. doi: 10.1182/blood-2002-09-2739. Epub 2003 Jan 9. Blood. 2003. PMID: 12522001 Free article.

4

Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors.

Grant S, Dent P. Grant S, et al. Among authors: dent p. Cell Cycle. 2002 Nov-Dec;1(6):383-8. doi: 10.4161/cc.1.6.260. Cell Cycle. 2002. PMID: 12548009 Review.

5

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S. Yu C, et al. Among authors: dent p. Cancer Res. 2003 Apr 15;63(8):1822-33. Cancer Res. 2003. PMID: 12702569

6

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.

Dai Y, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Mol Pharmacol. 2003 Dec;64(6):1402-9. doi: 10.1124/mol.64.6.1402. Mol Pharmacol. 2003. PMID: 14645670

7

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process.

Yu C, Rahmani M, Almenara J, Sausville EA, Dent P, Grant S. Yu C, et al. Among authors: dent p. Oncogene. 2004 Feb 19;23(7):1364-76. doi: 10.1038/sj.onc.1207248. Oncogene. 2004. PMID: 14647418

8

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.

Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Blood. 2004 Jul 15;104(2):509-18. doi: 10.1182/blood-2003-12-4121. Epub 2004 Mar 23. Blood. 2004. PMID: 15039284 Free article.

9

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.

Yu C, Rahmani M, Dent P, Grant S. Yu C, et al. Among authors: dent p. Exp Cell Res. 2004 May 1;295(2):555-66. doi: 10.1016/j.yexcr.2004.02.001. Exp Cell Res. 2004. PMID: 15093752

10

Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.

Gao N, Dai Y, Rahmani M, Dent P, Grant S. Gao N, et al. Among authors: dent p. Mol Pharmacol. 2004 Oct;66(4):956-63. doi: 10.1124/mol.104.002014. Epub 2004 Jul 2. Mol Pharmacol. 2004. PMID: 15235103

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