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Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.
Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W. Choi EK, et al. Among authors: wasco w. J Biol Chem. 2001 Jun 1;276(22):19197-204. doi: 10.1074/jbc.M008597200. Epub 2001 Mar 9. J Biol Chem. 2001. PMID: 11278424 Free article.
K., Luo, Y., Lilliehook, C., Crowley, A. C., Merriam, D. E., and Wasco, W. (1998) Nat. Med. 4, 1177-1181) and reverse the presenilin-mediated enhancement of calcium signaling (Leissring, M. A., Yamasaki, T. R., Wasco, W., Buxbaum, J. D., Parker, I., an …
K., Luo, Y., Lilliehook, C., Crowley, A. C., Merriam, D. E., and Wasco, W. (1998) Nat. Med. 4, 1177-1181) and reverse the pres …
Altered Abeta formation and long-term potentiation in a calsenilin knock-out.
Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD. Lilliehook C, et al. Among authors: wasco w. J Neurosci. 2003 Oct 8;23(27):9097-106. doi: 10.1523/JNEUROSCI.23-27-09097.2003. J Neurosci. 2003. PMID: 14534243 Free PMC article.
Calsenilin is degraded by the ubiquitin-proteasome pathway.
Jang C, Choi JK, Kim E, Park ES, Wasco W, Buxbaum JD, Kim YS, Choi EK. Jang C, et al. Among authors: wasco w. Biochem Biophys Res Commun. 2011 Feb 11;405(2):180-5. doi: 10.1016/j.bbrc.2010.12.137. Epub 2011 Jan 7. Biochem Biophys Res Commun. 2011. PMID: 21216226
57 results