Orr GA - Search Results

1

Insights into the mechanism of microtubule stabilization by Taxol.

Xiao H, Verdier-Pinard P, Fernandez-Fuentes N, Burd B, Angeletti R, Fiser A, Horwitz SB, Orr GA. Xiao H, et al. Among authors: orr ga. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10166-10173. doi: 10.1073/pnas.0603704103. Epub 2006 Jun 26. Proc Natl Acad Sci U S A. 2006. PMID: 16801540 Free PMC article.

2

Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.

Martello LA, Verdier-Pinard P, Shen HJ, He L, Torres K, Orr GA, Horwitz SB. Martello LA, et al. Among authors: orr ga. Cancer Res. 2003 Mar 15;63(6):1207-13. Cancer Res. 2003. PMID: 12649178

3

Mechanisms of Taxol resistance related to microtubules.

Orr GA, Verdier-Pinard P, McDaid H, Horwitz SB. Orr GA, et al. Oncogene. 2003 Oct 20;22(47):7280-95. doi: 10.1038/sj.onc.1206934. Oncogene. 2003. PMID: 14576838 Free PMC article. Review.

4

Novel molecules that interact with microtubules and have functional activity similar to Taxol.

He L, Orr GA, Horwitz SB. He L, et al. Among authors: orr ga. Drug Discov Today. 2001 Nov 15;6(22):1153-1164. doi: 10.1016/s1359-6446(01)02038-4. Drug Discov Today. 2001. PMID: 11700217

5

Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.

Verdier-Pinard P, Wang F, Martello L, Burd B, Orr GA, Horwitz SB. Verdier-Pinard P, et al. Among authors: orr ga. Biochemistry. 2003 May 13;42(18):5349-57. doi: 10.1021/bi027293o. Biochemistry. 2003. PMID: 12731876

6

Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.

Verdier-Pinard P, Wang F, Burd B, Angeletti RH, Horwitz SB, Orr GA. Verdier-Pinard P, et al. Among authors: orr ga. Biochemistry. 2003 Oct 21;42(41):12019-27. doi: 10.1021/bi0350147. Biochemistry. 2003. PMID: 14556633

7

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.

Yang CP, Verdier-Pinard P, Wang F, Lippaine-Horvath E, He L, Li D, Höfle G, Ojima I, Orr GA, Horwitz SB. Yang CP, et al. Among authors: orr ga. Mol Cancer Ther. 2005 Jun;4(6):987-95. doi: 10.1158/1535-7163.MCT-05-0024. Mol Cancer Ther. 2005. PMID: 15956256

8

Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics.

Verdier-Pinard P, Shahabi S, Wang F, Burd B, Xiao H, Goldberg GL, Orr GA, Horwitz SB. Verdier-Pinard P, et al. Among authors: orr ga. Biochemistry. 2005 Dec 6;44(48):15858-70. doi: 10.1021/bi051004p. Biochemistry. 2005. PMID: 16313188

9

A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.

Xia S, Kenesky CS, Rucker PV, Smith AB 3rd, Orr GA, Horwitz SB. Xia S, et al. Among authors: orr ga. Biochemistry. 2006 Oct 3;45(39):11762-75. doi: 10.1021/bi060497a. Biochemistry. 2006. PMID: 17002277

10

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin.

Rao S, Orr GA, Chaudhary AG, Kingston DG, Horwitz SB. Rao S, et al. Among authors: orr ga. J Biol Chem. 1995 Sep 1;270(35):20235-8. doi: 10.1074/jbc.270.35.20235. J Biol Chem. 1995. PMID: 7657589 Free article.

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