Geisler JG - Search Results

1

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM. Samuel VT, et al. Among authors: geisler jg. Diabetes. 2006 Jul;55(7):2042-50. doi: 10.2337/db05-0705. Diabetes. 2006. PMID: 16804074

2

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI. Samuel VT, et al. Among authors: geisler jg. J Clin Invest. 2007 Mar;117(3):739-45. doi: 10.1172/JCI30400. Epub 2007 Feb 22. J Clin Invest. 2007. PMID: 17318260 Free PMC article.

3

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI. Choi CS, et al. Among authors: geisler jg. J Biol Chem. 2007 Aug 3;282(31):22678-88. doi: 10.1074/jbc.M704213200. Epub 2007 May 27. J Biol Chem. 2007. PMID: 17526931 Free article.

4

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Savage DB, et al. Among authors: geisler jg. J Clin Invest. 2006 Mar;116(3):817-24. doi: 10.1172/JCI27300. Epub 2006 Feb 16. J Clin Invest. 2006. PMID: 16485039 Free PMC article.

5

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.

Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov VB, Church CD, Rodeheffer MS, Cline GW, Geisler JG, Bhanot S, Samuel VT. Beddow SA, et al. Among authors: geisler jg. Endocrinology. 2019 Jan 1;160(1):205-219. doi: 10.1210/en.2018-00630. Endocrinology. 2019. PMID: 30445425 Free PMC article.

6

Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide.

Geisler JG, Zawalich W, Zawalich K, Lakey JR, Stukenbrok H, Milici AJ, Soeller WC. Geisler JG, et al. Diabetes. 2002 Jul;51(7):2158-69. doi: 10.2337/diabetes.51.7.2158. Diabetes. 2002. PMID: 12086946

7

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA. Qi J, et al. Among authors: geisler jg. J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3. J Lipid Res. 2012. PMID: 22493088 Free PMC article.

8

Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents.

Patch RJ, Huang H, Patel S, Cheung W, Xu G, Zhao BP, Beauchamp DA, Rentzeperis D, Geisler JG, Askari HB, Liu J, Kasturi J, Towers M, Gaul MD, Player MR. Patch RJ, et al. Among authors: geisler jg. Eur J Med Chem. 2017 Sep 29;138:830-853. doi: 10.1016/j.ejmech.2017.07.015. Epub 2017 Jul 14. Eur J Med Chem. 2017. PMID: 28735214

9

Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

Patch RJ, Searle LL, Kim AJ, De D, Zhu X, Askari HB, O'Neill JC, Abad MC, Rentzeperis D, Liu J, Kemmerer M, Lin L, Kasturi J, Geisler JG, Lenhard JM, Player MR, Gaul MD. Patch RJ, et al. Among authors: geisler jg. J Med Chem. 2011 Feb 10;54(3):788-808. doi: 10.1021/jm101063h. Epub 2011 Jan 10. J Med Chem. 2011. PMID: 21218783

10

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

Klebig ML, Wilkinson JE, Geisler JG, Woychik RP. Klebig ML, et al. Among authors: geisler jg. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4728-32. doi: 10.1073/pnas.92.11.4728. Proc Natl Acad Sci U S A. 1995. PMID: 7761391 Free PMC article.

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