Kazantsev AG - Search Results

1

Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.

Altmann SM, Muryshev A, Fossale E, Maxwell MM, Norflus FN, Fox J, Hersch SM, Young AB, MacDonald ME, Abagyan R, Kazantsev AG. Altmann SM, et al. Among authors: kazantsev ag. Chem Biol. 2006 Jul;13(7):765-70. doi: 10.1016/j.chembiol.2006.05.012. Chem Biol. 2006. PMID: 16873024

2

Drug targeting of dysregulated transcription in Huntington's disease.

Kazantsev AG, Hersch SM. Kazantsev AG, et al. Prog Neurobiol. 2007 Nov;83(4):249-59. doi: 10.1016/j.pneurobio.2007.02.005. Epub 2007 Feb 23. Prog Neurobiol. 2007. PMID: 17379386 Free PMC article. Review.

3

Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.

Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG. Coufal M, et al. Among authors: kazantsev ag. J Biomol Screen. 2007 Apr;12(3):351-60. doi: 10.1177/1087057107299428. Epub 2007 Mar 22. J Biomol Screen. 2007. PMID: 17379859

4

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Outeiro TF, et al. Among authors: kazantsev ag. Science. 2007 Jul 27;317(5837):516-9. doi: 10.1126/science.1143780. Epub 2007 Jun 21. Science. 2007. PMID: 17588900

5

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. Chopra V, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. doi: 10.1073/pnas.0707842104. Epub 2007 Oct 9. Proc Natl Acad Sci U S A. 2007. PMID: 17925440 Free PMC article.

6

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.

Fox JH, Barber DS, Singh B, Zucker B, Swindell MK, Norflus F, Buzescu R, Chopra R, Ferrante RJ, Kazantsev A, Hersch SM. Fox JH, et al. J Neurochem. 2004 Oct;91(2):413-22. doi: 10.1111/j.1471-4159.2004.02726.x. J Neurochem. 2004. PMID: 15447674 Free article.

7

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.

Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH Jr. Maxwell MM, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3178-83. doi: 10.1073/pnas.0308726100. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981234 Free PMC article.

8

Two approaches to drug discovery in SOD1-mediated ALS.

Broom WJ, Auwarter KE, Ni J, Russel DE, Yeh LA, Maxwell MM, Glicksman M, Kazantsev AG, Brown RH Jr. Broom WJ, et al. Among authors: kazantsev ag. J Biomol Screen. 2006 Oct;11(7):729-35. doi: 10.1177/1087057106290937. Epub 2006 Aug 23. J Biomol Screen. 2006. PMID: 16928982

9

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, Landers JE, Luthi-Carter R, Abagyan R, Dinkova-Kostova AT, Steegborn C, Marsh JL, Lo DC, Thompson LM, Kazantsev AG. Quinti L, et al. Among authors: kazantsev ag. Cell Chem Biol. 2016 Jul 21;23(7):849-861. doi: 10.1016/j.chembiol.2016.05.015. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427231 Free article.

10

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.

Chopra V, Quinti L, Khanna P, Paganetti P, Kuhn R, Young AB, Kazantsev AG, Hersch S. Chopra V, et al. Among authors: kazantsev ag. J Huntingtons Dis. 2016 Dec 15;5(4):347-355. doi: 10.3233/JHD-160226. J Huntingtons Dis. 2016. PMID: 27983565 Free PMC article.

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