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Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Ichikawa W, Uetake H, Shirota Y, Yamada H, Takahashi T, Nihei Z, Sugihara K, Sasaki Y, Hirayama R. Ichikawa W, et al. Br J Cancer. 2003 Oct 20;89(8):1486-92. doi: 10.1038/sj.bjc.6601335. Br J Cancer. 2003. PMID: 14562021 Free PMC article. Clinical Trial.
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