Saeh JC - Search Results

1

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring.

Lyne PD, Lamb ML, Saeh JC. Lyne PD, et al. Among authors: saeh jc. J Med Chem. 2006 Aug 10;49(16):4805-8. doi: 10.1021/jm060522a. J Med Chem. 2006. PMID: 16884290

2

Lead hopping using SVM and 3D pharmacophore fingerprints.

Saeh JC, Lyne PD, Takasaki BK, Cosgrove DA. Saeh JC, et al. J Chem Inf Model. 2005 Jul-Aug;45(4):1122-33. doi: 10.1021/ci049732r. J Chem Inf Model. 2005. PMID: 16045307

3

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.

Hennessy EJ, Saeh JC, Sha L, MacIntyre T, Wang H, Larsen NA, Aquila BM, Ferguson AD, Laing NM, Omer CA. Hennessy EJ, et al. Among authors: saeh jc. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1690-4. doi: 10.1016/j.bmcl.2011.12.109. Epub 2011 Dec 31. Bioorg Med Chem Lett. 2012. PMID: 22264476

4

Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).

Hennessy EJ, Adam A, Aquila BM, Castriotta LM, Cook D, Hattersley M, Hird AW, Huntington C, Kamhi VM, Laing NM, Li D, MacIntyre T, Omer CA, Oza V, Patterson T, Repik G, Rooney MT, Saeh JC, Sha L, Vasbinder MM, Wang H, Whitston D. Hennessy EJ, et al. Among authors: saeh jc. J Med Chem. 2013 Dec 27;56(24):9897-919. doi: 10.1021/jm401075x. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24320998

5

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.

Hird AW, Aquila BM, Block MH, Hennessy EJ, Kamhi VM, Omer CA, Laing NM, Saeh JC, Sha L, Yang B. Hird AW, et al. Among authors: saeh jc. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1820-4. doi: 10.1016/j.bmcl.2014.02.016. Epub 2014 Feb 24. Bioorg Med Chem Lett. 2014. PMID: 24631189

6

Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.

Varnes JG, Gero T, Huang S, Diebold RB, Ogoe C, Grover PT, Su M, Mukherjee P, Saeh JC, MacIntyre T, Repik G, Dillman K, Byth K, Russell DJ, Ioannidis S. Varnes JG, et al. Among authors: saeh jc. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3026-33. doi: 10.1016/j.bmcl.2014.05.036. Epub 2014 May 20. Bioorg Med Chem Lett. 2014. PMID: 24881567

7

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.

Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA, Peng B, Pontz TW, Rivard-Costa C, Saeh JC, Thakur K, Ye Q, Zhang T, Lyne PD. Dowling JE, et al. Among authors: saeh jc. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. doi: 10.1021/ml400197u. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900749 Free PMC article.

8

Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.

Hennessy EJ, Grewal G, Byth K, Kamhi VM, Li D, Lyne P, Oza V, Ronco L, Rooney MT, Saeh JC, Su Q. Hennessy EJ, et al. Among authors: saeh jc. Bioorg Med Chem Lett. 2015;25(10):2041-5. doi: 10.1016/j.bmcl.2015.03.095. Epub 2015 Apr 8. Bioorg Med Chem Lett. 2015. PMID: 25890801

9

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.

Hennessy EJ, Oza V, Adam A, Byth K, Castriotta L, Grewal G, Hamilton GA, Kamhi VM, Lewis P, Li D, Lyne P, Öster L, Rooney MT, Saeh JC, Sha L, Su Q, Wen S, Xue Y, Yang B. Hennessy EJ, et al. Among authors: saeh jc. J Med Chem. 2015 Sep 10;58(17):7057-75. doi: 10.1021/acs.jmedchem.5b01078. Epub 2015 Aug 26. J Med Chem. 2015. PMID: 26291341

10

Development of a Series of Pyrrolopyridone MAT2A Inhibitors.

Atkinson SJ, Bagal SK, Argyrou A, Askin S, Cheung T, Chiarparin E, Coen M, Collie IT, Dale IL, De Fusco C, Dillman K, Evans L, Feron LJ, Foster AJ, Grondine M, Kantae V, Lamont GM, Lamont S, Lynch JT, Nilsson Lill S, Robb GR, Saeh J, Schimpl M, Scott JS, Smith J, Srinivasan B, Tentarelli S, Vazquez-Chantada M, Wagner D, Walsh JJ, Watson D, Williamson B. Atkinson SJ, et al. J Med Chem. 2024 Mar 28;67(6):4541-4559. doi: 10.1021/acs.jmedchem.3c01860. Epub 2024 Mar 11. J Med Chem. 2024. PMID: 38466661

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