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293,403 results

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Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase.
Smith L 2nd, Wong WC, Kiselyov AS, Burdzovic-Wizemann S, Mao Y, Xu Y, Duncton MA, Kim K, Piatnitski EL, Doody JF, Wang Y, Rosler RL, Milligan D, Columbus J, Balagtas C, Lee SP, Konovalov A, Hadari YR. Smith L 2nd, et al. Among authors: wang y. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5102-6. doi: 10.1016/j.bmcl.2006.07.031. Epub 2006 Aug 2. Bioorg Med Chem Lett. 2006. PMID: 16887347
Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Ouyang X, Chen X, Piatnitski EL, Kiselyov AS, He HY, Mao Y, Pattaropong V, Yu Y, Kim KH, Kincaid J, Smith L 2nd, Wong WC, Lee SP, Milligan DL, Malikzay A, Fleming J, Gerlak J, Deevi D, Doody JF, Chiang HH, Patel SN, Wang Y, Rolser RL, Kussie P, Labelle M, Tuma MC. Ouyang X, et al. Among authors: wang y. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. doi: 10.1016/j.bmcl.2005.08.056. Epub 2005 Sep 28. Bioorg Med Chem Lett. 2005. PMID: 16198562
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Ouyang X, Piatnitski EL, Pattaropong V, Chen X, He HY, Kiselyov AS, Velankar A, Kawakami J, Labelle M, Smith L 2nd, Lohman J, Lee SP, Malikzay A, Fleming J, Gerlak J, Wang Y, Rosler RL, Zhou K, Mitelman S, Camara M, Surguladze D, Doody JF, Tuma MC. Ouyang X, et al. Among authors: wang y. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1191-6. doi: 10.1016/j.bmcl.2005.11.094. Epub 2006 Jan 11. Bioorg Med Chem Lett. 2006. PMID: 16377187
Tricyclic azepine derivatives: pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors.
Smith L 2nd, Piatnitski EL, Kiselyov AS, Ouyang X, Chen X, Burdzovic-Wizemann S, Xu Y, Pan W, Chen X, Wang Y, Rosler RL, Patel SN, Chiang HH, Milligan DL, Columbus J, Wong WC, Doody JF, Hadari YR. Smith L 2nd, et al. Among authors: wang y. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1643-6. doi: 10.1016/j.bmcl.2005.12.018. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16412636
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.
Duncton MA, Piatnitski Chekler EL, Katoch-Rouse R, Sherman D, Wong WC, Smith LM 2nd, Kawakami JK, Kiselyov AS, Milligan DL, Balagtas C, Hadari YR, Wang Y, Patel SN, Rolster RL, Tonra JR, Surguladze D, Mitelman S, Kussie P, Bohlen P, Doody JF. Duncton MA, et al. Among authors: wang y. Bioorg Med Chem. 2009 Jan 15;17(2):731-40. doi: 10.1016/j.bmc.2008.11.049. Epub 2008 Nov 24. Bioorg Med Chem. 2009. PMID: 19101155
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
Chekler EL, Kiselyov AS, Ouyang X, Chen X, Pattaropong V, Wang Y, Tuma MC, Doody JF. Chekler EL, et al. Among authors: wang y. ACS Med Chem Lett. 2010 Aug 20;1(9):488-92. doi: 10.1021/ml1001568. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900236 Free PMC article.
Synthesis and evaluation of acylguanidine FXa inhibitors.
O'Connor SP, Atwal K, Li C, Liu EC, Seiler SM, Shi M, Shi Y, Stein PD, Wang Y. O'Connor SP, et al. Among authors: wang y. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4696-9. doi: 10.1016/j.bmcl.2008.07.004. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18644722
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.
Shi Y, Li C, O'Connor SP, Zhang J, Shi M, Bisaha SN, Wang Y, Sitkoff D, Pudzianowski AT, Huang C, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD. Shi Y, et al. Among authors: wang y. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. doi: 10.1016/j.bmcl.2009.10.084. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19896847
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