Harasym NL - Search Results

1

Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice.

Mayer LD, Harasym TO, Tardi PG, Harasym NL, Shew CR, Johnstone SA, Ramsay EC, Bally MB, Janoff AS. Mayer LD, et al. Among authors: harasym nl. Mol Cancer Ther. 2006 Jul;5(7):1854-63. doi: 10.1158/1535-7163.MCT-06-0118. Mol Cancer Ther. 2006. PMID: 16891472

2

Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios.

Harasym TO, Tardi PG, Harasym NL, Harvie P, Johnstone SA, Mayer LD. Harasym TO, et al. Among authors: harasym nl. Oncol Res. 2007;16(8):361-74. doi: 10.3727/000000006783980937. Oncol Res. 2007. PMID: 17913044

3

In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine.

Webb MS, Johnstone S, Morris TJ, Kennedy A, Gallagher R, Harasym N, Harasym T, Shew CR, Tardi P, Dragowska WH, Mayer LD, Bally MB. Webb MS, et al. Eur J Pharm Biopharm. 2007 Mar;65(3):289-99. doi: 10.1016/j.ejpb.2006.10.007. Epub 2006 Oct 17. Eur J Pharm Biopharm. 2007. PMID: 17123800

4

Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo.

Tardi PG, Gallagher RC, Johnstone S, Harasym N, Webb M, Bally MB, Mayer LD. Tardi PG, et al. Biochim Biophys Acta. 2007 Mar;1768(3):678-87. doi: 10.1016/j.bbamem.2006.11.014. Epub 2006 Dec 6. Biochim Biophys Acta. 2007. PMID: 17208196 Free article.

5

In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy.

Tardi P, Johnstone S, Harasym N, Xie S, Harasym T, Zisman N, Harvie P, Bermudes D, Mayer L. Tardi P, et al. Leuk Res. 2009 Jan;33(1):129-39. doi: 10.1016/j.leukres.2008.06.028. Epub 2008 Aug 3. Leuk Res. 2009. PMID: 18676016

6

Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates.

Ansell SM, Johnstone SA, Tardi PG, Lo L, Xie S, Shu Y, Harasym TO, Harasym NL, Williams L, Bermudes D, Liboiron BD, Saad W, Prud'homme RK, Mayer LD. Ansell SM, et al. Among authors: harasym nl. J Med Chem. 2008 Jun 12;51(11):3288-96. doi: 10.1021/jm800002y. Epub 2008 May 9. J Med Chem. 2008. PMID: 18465845

7

Liposomal irinotecan: formulation development and therapeutic assessment in murine xenograft models of colorectal cancer.

Messerer CL, Ramsay EC, Waterhouse D, Ng R, Simms EM, Harasym N, Tardi P, Mayer LD, Bally MB. Messerer CL, et al. Clin Cancer Res. 2004 Oct 1;10(19):6638-49. doi: 10.1158/1078-0432.CCR-04-0221. Clin Cancer Res. 2004. PMID: 15475454

8

Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil.

Hare JI, Neijzen RW, Anantha M, Dos Santos N, Harasym N, Webb MS, Allen TM, Bally MB, Waterhouse DN. Hare JI, et al. PLoS One. 2013 Apr 23;8(4):e62349. doi: 10.1371/journal.pone.0062349. Print 2013. PLoS One. 2013. PMID: 23626804 Free PMC article.

9

Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.

Waterhouse DN, Sutherland BW, Santos ND, Masin D, Osooly M, Strutt D, Ostlund C, Anantha M, Harasym N, Manisali I, Wehbe M, Bally MB, Webb MS. Waterhouse DN, et al. Invest New Drugs. 2014 Dec;32(6):1071-82. doi: 10.1007/s10637-014-0138-x. Epub 2014 Jul 27. Invest New Drugs. 2014. PMID: 25064374 Free PMC article.

10

Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles.

Zhigaltsev IV, Winters G, Srinivasulu M, Crawford J, Wong M, Amankwa L, Waterhouse D, Masin D, Webb M, Harasym N, Heller L, Bally MB, Ciufolini MA, Cullis PR, Maurer N. Zhigaltsev IV, et al. J Control Release. 2010 Jun 15;144(3):332-40. doi: 10.1016/j.jconrel.2010.02.029. Epub 2010 Mar 2. J Control Release. 2010. PMID: 20202473

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