Ohkanda J - Search Results

1

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

Delarue FL, Adnane J, Joshi B, Blaskovich MA, Wang DA, Hawker J, Bizouarn F, Ohkanda J, Zhu K, Hamilton AD, Chellappan S, Sebti SM. Delarue FL, et al. Among authors: ohkanda j. Oncogene. 2007 Feb 1;26(5):633-40. doi: 10.1038/sj.onc.1209819. Epub 2006 Aug 14. Oncogene. 2007. PMID: 16909123

2

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.

Ohkanda J, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Prog Cell Cycle Res. 2003;5:211-7. Prog Cell Cycle Res. 2003. PMID: 14593715 Review.

3

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Sun J, et al. Among authors: ohkanda j. Cancer Res. 1999 Oct 1;59(19):4919-26. Cancer Res. 1999. PMID: 10519405

4

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM. Adnane J, et al. Among authors: ohkanda j. Oncogene. 2000 Nov 16;19(48):5525-33. doi: 10.1038/sj.onc.1203920. Oncogene. 2000. PMID: 11114730

5

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. Crespo NC, et al. Among authors: ohkanda j. J Biol Chem. 2001 May 11;276(19):16161-7. doi: 10.1074/jbc.M006213200. Epub 2001 Jan 11. J Biol Chem. 2001. PMID: 11154688 Free article.

6

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

Crespo NC, Delarue F, Ohkanda J, Carrico D, Hamilton AD, Sebti SM. Crespo NC, et al. Among authors: ohkanda j. Cell Death Differ. 2002 Jul;9(7):702-9. doi: 10.1038/sj.cdd.4401023. Cell Death Differ. 2002. PMID: 12058275

7

Inhibitors of protein farnesyltransferase as novel anticancer agents.

Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Curr Top Med Chem. 2002 Mar;2(3):303-23. doi: 10.2174/1568026023394281. Curr Top Med Chem. 2002. PMID: 11944822 Review.

8

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton AD, Sebti SM. Sun J, et al. Among authors: ohkanda j. Cancer Res. 2003 Dec 15;63(24):8922-9. Cancer Res. 2003. PMID: 14695209

9

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

Vasudevan A, Qian Y, Vogt A, Blaskovich MA, Ohkanda J, Sebti SM, Hamilton AD. Vasudevan A, et al. Among authors: ohkanda j. J Med Chem. 1999 Apr 22;42(8):1333-40. doi: 10.1021/jm9900873. J Med Chem. 1999. PMID: 10212118

10

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.

Bolick SC, Landowski TH, Boulware D, Oshiro MM, Ohkanda J, Hamilton AD, Sebti SM, Dalton WS. Bolick SC, et al. Among authors: ohkanda j. Leukemia. 2003 Feb;17(2):451-7. doi: 10.1038/sj.leu.2402832. Leukemia. 2003. PMID: 12592346

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