Sawyers CL - Search Results

1

Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.

Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, Mischel PS. Wang MY, et al. Among authors: sawyers cl. Cancer Res. 2006 Aug 15;66(16):7864-9. doi: 10.1158/0008-5472.CAN-04-4392. Cancer Res. 2006. PMID: 16912159

2

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.

Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. Wu X, et al. Among authors: sawyers cl. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91. doi: 10.1073/pnas.95.26.15587. Proc Natl Acad Sci U S A. 1998. PMID: 9861013 Free PMC article.

3

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON, Said J, Reiter RE, Sawyers CL. Craft N, et al. Among authors: sawyers cl. Cancer Res. 1999 Oct 1;59(19):5030-6. Cancer Res. 1999. PMID: 10519419

4

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.

Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE. Wu X, et al. Among authors: sawyers cl. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4233-8. doi: 10.1073/pnas.97.8.4233. Proc Natl Acad Sci U S A. 2000. PMID: 10760291 Free PMC article.

5

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL. Neshat MS, et al. Among authors: sawyers cl. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10314-9. doi: 10.1073/pnas.171076798. Epub 2001 Aug 14. Proc Natl Acad Sci U S A. 2001. PMID: 11504908 Free PMC article.

6

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

Vivanco I, Sawyers CL. Vivanco I, et al. Among authors: sawyers cl. Nat Rev Cancer. 2002 Jul;2(7):489-501. doi: 10.1038/nrc839. Nat Rev Cancer. 2002. PMID: 12094235 Review. No abstract available.

7

Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia.

Sawyers CL. Sawyers CL. Cancer Cell. 2002 Jun;1(5):413-5. doi: 10.1016/s1535-6108(02)00080-6. Cancer Cell. 2002. PMID: 12124170 Free article. Review.

8

The emergence of resistance to targeted cancer therapeutics.

Mellinghoff IK, Sawyers CL. Mellinghoff IK, et al. Among authors: sawyers cl. Pharmacogenomics. 2002 Sep;3(5):603-23. doi: 10.1517/14622416.3.5.603. Pharmacogenomics. 2002. PMID: 12223047 Review.

9

Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.

Mellinghoff IK, Tran C, Sawyers CL. Mellinghoff IK, et al. Among authors: sawyers cl. Cancer Res. 2002 Sep 15;62(18):5254-9. Cancer Res. 2002. PMID: 12234993

10

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.

Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS. Choe G, et al. Among authors: sawyers cl. Cancer Res. 2003 Jun 1;63(11):2742-6. Cancer Res. 2003. PMID: 12782577

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