Siemers ER - Search Results

1

New pathways in drug discovery for Alzheimer's disease.

Siemers ER, Dean RA, Demattos R, May PC. Siemers ER, et al. Curr Neurol Neurosci Rep. 2006 Sep;6(5):372-8. doi: 10.1007/s11910-996-0017-8. Curr Neurol Neurosci Rep. 2006. PMID: 16928346 Review.

2

Revised criteria for the diagnosis and staging of Alzheimer's disease.

Jack CR Jr, Andrews SJ, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC. Jack CR Jr, et al. Nat Med. 2024 Aug;30(8):2121-2124. doi: 10.1038/s41591-024-02988-7. Nat Med. 2024. PMID: 38942991 No abstract available.

3

Imaging-based measures of disease progression in clinical trials of disease-modifying drugs for Alzheimer disease.

Matthews B, Siemers ER, Mozley PD. Matthews B, et al. Among authors: siemers er. Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):146-59. Am J Geriatr Psychiatry. 2003. PMID: 12611744 Review.

4

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers.

Siemers E, Skinner M, Dean RA, Gonzales C, Satterwhite J, Farlow M, Ness D, May PC. Siemers E, et al. Clin Neuropharmacol. 2005 May-Jun;28(3):126-32. doi: 10.1097/01.wnf.0000167360.27670.29. Clin Neuropharmacol. 2005. PMID: 15965311 Clinical Trial.

5

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Siemers ER, et al. Neurology. 2006 Feb 28;66(4):602-4. doi: 10.1212/01.WNL.0000198762.41312.E1. Neurology. 2006. PMID: 16505324 Clinical Trial.

6

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.

Oe T, Ackermann BL, Inoue K, Berna MJ, Garner CO, Gelfanova V, Dean RA, Siemers ER, Holtzman DM, Farlow MR, Blair IA. Oe T, et al. Among authors: siemers er. Rapid Commun Mass Spectrom. 2006;20(24):3723-35. doi: 10.1002/rcm.2787. Rapid Commun Mass Spectrom. 2006. PMID: 17117458

7

Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry.

Gelfanova V, Higgs RE, Dean RA, Holtzman DM, Farlow MR, Siemers ER, Boodhoo A, Qian YW, He X, Jin Z, Fisher DL, Cox KL, Hale JE. Gelfanova V, et al. Among authors: siemers er. Brief Funct Genomic Proteomic. 2007 Jun;6(2):149-58. doi: 10.1093/bfgp/elm010. Epub 2007 Jun 20. Brief Funct Genomic Proteomic. 2007. PMID: 17584762

8

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

9

Partnership between academia and industry for drug discovery in Alzheimer's disease.

Ivinson AJ, Lane R, May PC, Hosford DA, Carrillo MC, Siemers ER. Ivinson AJ, et al. Among authors: siemers er. Alzheimers Dement. 2008 Mar;4(2):80-8. doi: 10.1016/j.jalz.2008.02.004. Alzheimers Dement. 2008. PMID: 18631952

10

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.

Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Sherzai A, Sowell BB, Aisen PS, Thal LJ. Fleisher AS, et al. Among authors: siemers er. Arch Neurol. 2008 Aug;65(8):1031-8. doi: 10.1001/archneur.65.8.1031. Arch Neurol. 2008. PMID: 18695053 Free PMC article. Clinical Trial.

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