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Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production.
Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F. Coll AP, et al. Among authors: tung yc. J Endocrinol. 2006 Aug;190(2):515-25. doi: 10.1677/joe.1.06749. J Endocrinol. 2006. PMID: 16899584 Free PMC article.
Orexin expression is regulated by alpha-melanocyte-stimulating hormone.
López M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O'Rahilly S, Vidal-Puig A, Diéguez C, Coll AP. López M, et al. Among authors: tung yc. J Neuroendocrinol. 2007 Sep;19(9):703-7. doi: 10.1111/j.1365-2826.2007.01577.x. J Neuroendocrinol. 2007. PMID: 17680885 Free PMC article.
Where to go with FTO?
Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP. Larder R, et al. Among authors: tung yc. Trends Endocrinol Metab. 2011 Feb;22(2):53-9. doi: 10.1016/j.tem.2010.11.001. Epub 2010 Dec 4. Trends Endocrinol Metab. 2011. PMID: 21131211 Review.
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD. McMurray F, et al. Among authors: tung yc. PLoS Genet. 2013;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300482 Free PMC article.
Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.
Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP. Larder R, et al. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15. Proc Natl Acad Sci U S A. 2017. PMID: 28811369 Free PMC article.
GDF15 mediates the effects of metformin on body weight and energy balance.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Coll AP, et al. Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Nature. 2020. PMID: 31875646 Free PMC article. Clinical Trial.
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Cimino I, et al. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8. Sci Rep. 2021. PMID: 34475432 Free PMC article.
445 results