Sham HL - Search Results

1

Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.

Clark RF, Zhang T, Xin Z, Liu G, Wang Y, Hansen TM, Wang X, Wang R, Zhang X, Frevert EU, Camp HS, Beutel BA, Sham HL, Gu YG. Clark RF, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6078-81. doi: 10.1016/j.bmcl.2006.08.100. Epub 2006 Sep 14. Bioorg Med Chem Lett. 2006. PMID: 16973360

2

Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.

Richards S, Sorensen B, Jae HS, Winn M, Chen Y, Wang J, Fung S, Monzon K, Frevert EU, Jacobson P, Sham H, Link JT. Richards S, et al. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6241-5. doi: 10.1016/j.bmcl.2006.09.035. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17000111

3

Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.

Liu B, Liu G, Xin Z, Serby MD, Zhao H, Schaefer VG, Falls HD, Kaszubska W, Collins CA, Sham HL. Liu B, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5223-6. doi: 10.1016/j.bmcl.2004.06.060. Bioorg Med Chem Lett. 2004. PMID: 15380232

4

Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation.

Zhao H, Xin Z, Liu G, Schaefer VG, Falls HD, Kaszubska W, Collins CA, Sham HL. Zhao H, et al. Among authors: sham hl. J Med Chem. 2004 Dec 30;47(27):6655-7. doi: 10.1021/jm0491750. J Med Chem. 2004. PMID: 15615511

5

Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.

Xin Z, Zhao H, Serby MD, Liu B, Schaefer VG, Falls DH, Kaszubska W, Colins CA, Sham HL, Liu G. Xin Z, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1201-4. doi: 10.1016/j.bmcl.2004.11.075. Bioorg Med Chem Lett. 2005. PMID: 15686942

6

Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.

Zhao H, Xin Z, Patel JR, Nelson LT, Liu B, Szczepankiewicz BG, Schaefer VG, Falls HD, Kaszubska W, Collins CA, Sham HL, Liu G. Zhao H, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1825-8. doi: 10.1016/j.bmcl.2005.02.026. Bioorg Med Chem Lett. 2005. PMID: 15780615

7

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.

Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G. Liu M, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2006 May 15;16(10):2590-4. doi: 10.1016/j.bmcl.2006.02.046. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16527482

8

Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.

Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Zhang T, Hansen TM, Liu G, Xin Z, Wang X, Wang R, McNally T, Zinker BA, Frevert EU, Camp HS, Beutel BA, Sham HL. Gu YG, et al. Among authors: sham hl. J Med Chem. 2006 Jun 29;49(13):3770-3. doi: 10.1021/jm060484v. J Med Chem. 2006. PMID: 16789734

9

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

Liu G, Zhao H, Liu B, Xin Z, Liu M, Kosogof C, Szczepankiewicz BG, Wang S, Clampit JE, Gum RJ, Haasch DL, Trevillyan JM, Sham HL. Liu G, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5723-30. doi: 10.1016/j.bmcl.2006.08.097. Epub 2006 Sep 12. Bioorg Med Chem Lett. 2006. PMID: 16971120

10

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.

Liu G, Zhao H, Liu B, Xin Z, Liu M, Serby MD, Lubbers NL, Widomski DL, Polakowski JS, Beno DW, Trevillyan JM, Sham HL. Liu G, et al. Among authors: sham hl. Bioorg Med Chem Lett. 2007 Jan 15;17(2):495-500. doi: 10.1016/j.bmcl.2006.10.013. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17055723

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