Larson G - Search Results

1

2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules.

Kamath K, Okouneva T, Larson G, Panda D, Wilson L, Jordan MA. Kamath K, et al. Among authors: larson g. Mol Cancer Ther. 2006 Sep;5(9):2225-33. doi: 10.1158/1535-7163.MCT-06-0113. Mol Cancer Ther. 2006. PMID: 16985056 Free article.

2

Interaction of the antitumor compound cryptophycin-52 with tubulin.

Panda D, Ananthnarayan V, Larson G, Shih C, Jordan MA, Wilson L. Panda D, et al. Among authors: larson g. Biochemistry. 2000 Nov 21;39(46):14121-7. doi: 10.1021/bi0010827. Biochemistry. 2000. PMID: 11087360

3

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.

Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D. Carlessi L, et al. Among authors: larson g. Mol Cancer Ther. 2007 Mar;6(3):935-44. doi: 10.1158/1535-7163.MCT-06-0567. Mol Cancer Ther. 2007. PMID: 17363488

4

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.

Iverson C, Larson G, Lai C, Yeh LT, Dadson C, Weingarten P, Appleby T, Vo T, Maderna A, Vernier JM, Hamatake R, Miner JN, Quart B. Iverson C, et al. Among authors: larson g. Cancer Res. 2009 Sep 1;69(17):6839-47. doi: 10.1158/0008-5472.CAN-09-0679. Epub 2009 Aug 25. Cancer Res. 2009. PMID: 19706763

5

Identification of novel, selective and potent Chk2 inhibitors.

Larson G, Yan S, Chen H, Rong F, Hong Z, Wu JZ. Larson G, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):172-5. doi: 10.1016/j.bmcl.2006.09.067. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17035018

6

Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin.

Wu JZ, Larson G, Hong Z. Wu JZ, et al. Among authors: larson g. Antimicrob Agents Chemother. 2004 Oct;48(10):4006-8. doi: 10.1128/AAC.48.10.4006-4008.2004. Antimicrob Agents Chemother. 2004. PMID: 15388466 Free PMC article.

7

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

Rong F, Chow S, Yan S, Larson G, Hong Z, Wu J. Rong F, et al. Among authors: larson g. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1663-6. doi: 10.1016/j.bmcl.2006.12.103. Epub 2007 Jan 8. Bioorg Med Chem Lett. 2007. PMID: 17258458

8

Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes.

Wu JZ, Larson G, Walker H, Shim JH, Hong Z. Wu JZ, et al. Among authors: larson g. Antimicrob Agents Chemother. 2005 Jun;49(6):2164-71. doi: 10.1128/AAC.49.6.2164-2171.2005. Antimicrob Agents Chemother. 2005. PMID: 15917509 Free PMC article.

9

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N. Yan S, et al. Among authors: larson g. Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. doi: 10.1016/j.bmcl.2006.09.095. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17049849

10

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N. Yan S, et al. Among authors: larson g. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5888-91. doi: 10.1016/j.bmcl.2006.08.056. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934455

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