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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schürmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Atreya R, et al. Nat Med. 2000 May;6(5):583-8. doi: 10.1038/75068. Nat Med. 2000. PMID: 10802717
IL-6 trans-signaling: the heat is on.
Rose-John S, Neurath MF. Rose-John S, et al. Immunity. 2004 Jan;20(1):2-4. doi: 10.1016/s1074-7613(04)00003-2. Immunity. 2004. PMID: 14738759 Free article.
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Heink S, et al. Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Nat Immunol. 2017. PMID: 27893700 Free PMC article.
611 results