DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops.
Mendes IC, Dos Reis Bertoldo W, Miranda-Junior AS, Assis AV, Repolês BM, Ferreira WRR, Chame DF, Souza DL, Pavani RS, Macedo AM, Franco GR, Serra E, Perdomo V, Menck CFM, da Silva Leandro G, Fragoso SP, Barbosa Elias MCQ, Machado CR.
Mendes IC, et al. Among authors: machado cr.
DNA Repair (Amst). 2024 Sep;141:103726. doi: 10.1016/j.dnarep.2024.103726. Epub 2024 Jul 27.
DNA Repair (Amst). 2024.
PMID: 39096697