O'Brien JA - Search Results

1

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

Goldman ME, Nunberg JH, O'Brien JA, Quintero JC, Schleif WA, Freund KF, Gaul SL, Saari WS, Wai JS, Hoffman JM, et al. Goldman ME, et al. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6863-7. doi: 10.1073/pnas.88.15.6863. Proc Natl Acad Sci U S A. 1991. PMID: 1713693 Free PMC article.

2

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.

Hoffman JM, Wai JS, Thomas CM, Levin RB, O'Brien JA, Goldman ME. Hoffman JM, et al. J Med Chem. 1992 Oct 16;35(21):3784-91. doi: 10.1021/jm00099a006. J Med Chem. 1992. PMID: 1279172

3

Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices.

Balani SK, Pitzenberger SM, Kauffman LR, Arison BH, Ramjit HG, Goldman ME, O'Brien JA, King JD, Hoffman JM, Rooney CS, et al. Balani SK, et al. Drug Metab Dispos. 1992 Nov-Dec;20(6):869-76. Drug Metab Dispos. 1992. PMID: 1283569

4

L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.

Goldman ME, O'Brien JA, Ruffing TL, Nunberg JH, Schleif WA, Quintero JC, Siegl PK, Hoffman JM, Smith AM, Emini EA. Goldman ME, et al. Antimicrob Agents Chemother. 1992 May;36(5):1019-23. doi: 10.1128/AAC.36.5.1019. Antimicrob Agents Chemother. 1992. PMID: 1380788 Free PMC article.

5

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.

Nunberg JH, Schleif WA, Boots EJ, O'Brien JA, Quintero JC, Hoffman JM, Emini EA, Goldman ME. Nunberg JH, et al. J Virol. 1991 Sep;65(9):4887-92. doi: 10.1128/JVI.65.9.4887-4892.1991. J Virol. 1991. PMID: 1714522 Free PMC article.

6

2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.

Saari WS, Hoffman JM, Wai JS, Fisher TE, Rooney CS, Smith AM, Thomas CM, Goldman ME, O'Brien JA, Nunberg JH, et al. Saari WS, et al. J Med Chem. 1991 Sep;34(9):2922-5. doi: 10.1021/jm00113a036. J Med Chem. 1991. PMID: 1716683 No abstract available.

7

A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors.

Goldman ME, O'Brien JA, Ruffing TL, Schleif WA, Sardana VV, Byrnes VW, Condra JH, Hoffman JM, Emini EA. Goldman ME, et al. Antimicrob Agents Chemother. 1993 May;37(5):947-9. doi: 10.1128/AAC.37.5.947. Antimicrob Agents Chemother. 1993. PMID: 7685996 Free PMC article.

8

Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.

Balani SK, Kauffman LR, Arison BH, Olah TV, Goldman ME, Varga SL, O'Brien JA, Ramjit HG, Rooney CS, Hoffman JM, et al. Balani SK, et al. Drug Metab Dispos. 1994 Mar-Apr;22(2):200-5. Drug Metab Dispos. 1994. PMID: 7516852

9

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Tucker TJ, Lyle TA, Wiscount CM, Britcher SF, Young SD, Sanders WM, Lumma WC, Goldman ME, O'Brien JA, Ball RG, et al. Tucker TJ, et al. J Med Chem. 1994 Jul 22;37(15):2437-44. doi: 10.1021/jm00041a023. J Med Chem. 1994. PMID: 7520079

10

A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels.

O'Brien JA, Ostovic D, Schorn TW, Smith SJ, Ruffing TL, Siegl PK, Goldman ME. O'Brien JA, et al. Life Sci. 1993;52(3):243-9. doi: 10.1016/0024-3205(93)90215-o. Life Sci. 1993. PMID: 7678687

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

267 results

Search Page

Filters