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Activating mutations of N-WASP alter Shigella pathogenesis.
Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB. Adamovich DA, et al. Among authors: worth a. Biochem Biophys Res Commun. 2009 Jul 3;384(3):284-9. doi: 10.1016/j.bbrc.2009.04.050. Epub 2009 Apr 18. Biochem Biophys Res Commun. 2009. PMID: 19379711 Free PMC article.
Phosphorylation of WASp is a key regulator of activity and stability in vivo.
Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ. Blundell MP, et al. Among authors: worth a. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15738-43. doi: 10.1073/pnas.0904346106. Epub 2009 Sep 1. Proc Natl Acad Sci U S A. 2009. PMID: 19805221 Free PMC article.
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS. Baptista MA, et al. Among authors: worth aj. Nat Commun. 2016 Jul 18;7:12175. doi: 10.1038/ncomms12175. Nat Commun. 2016. PMID: 27425374 Free PMC article.
Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans.
Tuijnenburg P, Lango Allen H, Burns SO, Greene D, Jansen MH, Staples E, Stephens J, Carss KJ, Biasci D, Baxendale H, Thomas M, Chandra A, Kiani-Alikhan S, Longhurst HJ, Seneviratne SL, Oksenhendler E, Simeoni I, de Bree GJ, Tool ATJ, van Leeuwen EMM, Ebberink EHTM, Meijer AB, Tuna S, Whitehorn D, Brown M, Turro E, Thrasher AJ, Smith KGC, Thaventhiran JE, Kuijpers TW; NIHR BioResource–Rare Diseases Consortium. Tuijnenburg P, et al. J Allergy Clin Immunol. 2018 Oct;142(4):1285-1296. doi: 10.1016/j.jaci.2018.01.039. Epub 2018 Mar 2. J Allergy Clin Immunol. 2018. PMID: 29477724 Free PMC article.
646 results