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Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities.
Fiser R, Masín J, Basler M, Krusek J, Spuláková V, Konopásek I, Sebo P. Fiser R, et al. Among authors: basler m. J Biol Chem. 2007 Feb 2;282(5):2808-20. doi: 10.1074/jbc.M609979200. Epub 2006 Dec 4. J Biol Chem. 2007. PMID: 17148436 Free article.
Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.
Fiser R, Masin J, Bumba L, Pospisilova E, Fayolle C, Basler M, Sadilkova L, Adkins I, Kamanova J, Cerny J, Konopasek I, Osicka R, Leclerc C, Sebo P. Fiser R, et al. Among authors: basler m. PLoS Pathog. 2012;8(4):e1002580. doi: 10.1371/journal.ppat.1002580. Epub 2012 Apr 5. PLoS Pathog. 2012. PMID: 22496638 Free PMC article.
RTX proteins: a highly diverse family secreted by a common mechanism.
Linhartová I, Bumba L, Mašín J, Basler M, Osička R, Kamanová J, Procházková K, Adkins I, Hejnová-Holubová J, Sadílková L, Morová J, Sebo P. Linhartová I, et al. Among authors: basler m. FEMS Microbiol Rev. 2010 Nov;34(6):1076-112. doi: 10.1111/j.1574-6976.2010.00231.x. FEMS Microbiol Rev. 2010. PMID: 20528947 Free PMC article. Review.
164 results