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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Cnop M, et al. Among authors: hekerman p. J Biol Chem. 2007 Feb 9;282(6):3989-97. doi: 10.1074/jbc.M607627200. Epub 2006 Dec 8. J Biol Chem. 2007. PMID: 17158450 Free article.
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M. Cunha DA, et al. Among authors: hekerman p. J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17. J Cell Sci. 2008. PMID: 18559892 Free PMC article.