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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Brüggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ. Akasaka T, et al. Among authors: atherton mg. Blood. 2007 Apr 15;109(8):3451-61. doi: 10.1182/blood-2006-08-041012. Epub 2006 Dec 14. Blood. 2007. PMID: 17170124 Free article. Clinical Trial.
Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization.
Strefford JC, Worley H, Barber K, Wright S, Stewart AR, Robinson HM, Bettney G, van Delft FW, Atherton MG, Davies T, Griffiths M, Hing S, Ross FM, Talley P, Saha V, Moorman AV, Harrison CJ. Strefford JC, et al. Among authors: atherton mg. Oncogene. 2007 Jun 21;26(29):4306-18. doi: 10.1038/sj.onc.1210190. Epub 2007 Jan 22. Oncogene. 2007. PMID: 17237825
The gene expression signature associated with TP53 mutation/deletion in chronic lymphocytic leukaemia is dominated by the under-expression of TP53 and other genes on chromosome 17p.
Lin K, Lane B, Carter A, Johnson GG, Onwuazor O, Oates M, Zenz T, Stilgenbauer S, Atherton M, Douglas A, Ebrahimi B, Sherrington PD, Pettitt AR. Lin K, et al. Br J Haematol. 2013 Jan;160(1):53-62. doi: 10.1111/bjh.12092. Epub 2012 Oct 30. Br J Haematol. 2013. PMID: 23110309 Free article.