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Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA. Nashmi R, et al. J Neurosci. 2003 Dec 17;23(37):11554-67. doi: 10.1523/JNEUROSCI.23-37-11554.2003. J Neurosci. 2003. PMID: 14684858 Free PMC article.
Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.
Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, Whiteaker P, Huang Q, McClure-Begley T, Lindstrom JM, Labarca C, Collins AC, Marks MJ, Lester HA. Nashmi R, et al. J Neurosci. 2007 Aug 1;27(31):8202-18. doi: 10.1523/JNEUROSCI.2199-07.2007. J Neurosci. 2007. PMID: 17670967 Free PMC article.
Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.
Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA. Labarca C, et al. Among authors: nashmi r. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2786-91. doi: 10.1073/pnas.041582598. Epub 2001 Feb 20. Proc Natl Acad Sci U S A. 2001. PMID: 11226318 Free PMC article.
44 results