Gawron LS - Search Results

1

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.

Kennedy DR, Gawron LS, Ju J, Liu W, Shen B, Beerman TA. Kennedy DR, et al. Among authors: gawron ls. Cancer Res. 2007 Jan 15;67(2):773-81. doi: 10.1158/0008-5472.CAN-06-2893. Cancer Res. 2007. PMID: 17234789

2

The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction.

McHugh MM, Gawron LS, Matsui S, Beerman TA. McHugh MM, et al. Among authors: gawron ls. Cancer Res. 2005 Jun 15;65(12):5344-51. doi: 10.1158/0008-5472.CAN-05-0015. Cancer Res. 2005. PMID: 15958582

3

C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.

Beerman TA, Gawron LS, Shin S, Shen B, McHugh MM. Beerman TA, et al. Among authors: gawron ls. Cancer Res. 2009 Jan 15;69(2):593-8. doi: 10.1158/0008-5472.CAN-08-2753. Cancer Res. 2009. PMID: 19147573 Free PMC article.

4

The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.

Beerman TA, Gawron LS, Shen B, Kennedy DR. Beerman TA, et al. Among authors: gawron ls. DNA Repair (Amst). 2014 Sep;21:165-70. doi: 10.1016/j.dnarep.2014.06.001. Epub 2014 Jun 28. DNA Repair (Amst). 2014. PMID: 24986640 Free PMC article.

5

Topoisomerase II-mediated DNA damage of episomes in tumor-bearing mice.

Cullinan EB, Gawron LS, Rustum YM, Beerman TA. Cullinan EB, et al. Among authors: gawron ls. Cancer Res. 1990 Oct 1;50(19):6154-7. Cancer Res. 1990. PMID: 2169334

6

Inhibiting transcription factor/DNA complexes using fluorescent microgonotropens (FMGTs).

White CM, Satz AL, Gawron LS, Bruice TC, Beerman TA. White CM, et al. Among authors: gawron ls. Biochim Biophys Acta. 2002 Feb 20;1574(1):100-8. doi: 10.1016/s0167-4781(01)00351-7. Biochim Biophys Acta. 2002. PMID: 11955618

7

Effects of the DNA-damaging enediyne C-1027 on intracellular SV40 and genomic DNA in green monkey kidney BSC-1 cells.

McHugh MM, Woynarowski JM, Gawron LS, Otani T, Beerman TA. McHugh MM, et al. Among authors: gawron ls. Biochemistry. 1995 Feb 7;34(5):1805-14. doi: 10.1021/bi00005a038. Biochemistry. 1995. PMID: 7849041

8

Targeting E2F1-DNA complexes with microgonotropen DNA binding agents.

Chiang SY, Bruice TC, Azizkhan JC, Gawron L, Beerman TA. Chiang SY, et al. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2811-6. doi: 10.1073/pnas.94.7.2811. Proc Natl Acad Sci U S A. 1997. PMID: 9096302 Free PMC article.

9

Extrachromosomal chromatin: novel target for bleomycin cleavage in cells and solid tumors.

Cullinan EB, Gawron LS, Rustum YM, Beerman TA. Cullinan EB, et al. Among authors: gawron ls. Biochemistry. 1991 Mar 26;30(12):3055-61. doi: 10.1021/bi00226a011. Biochemistry. 1991. PMID: 1706627

10

Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065.

Zsido TJ, Woynarowski JM, Baker RM, Gawron LS, Beerman TA. Zsido TJ, et al. Among authors: gawron ls. Biochemistry. 1991 Apr 16;30(15):3733-8. doi: 10.1021/bi00229a021. Biochemistry. 1991. PMID: 1849736

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