Lira R - Search Results

1

Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin.

Lira R, Roush WR. Lira R, et al. Org Lett. 2007 Feb 1;9(3):533-6. doi: 10.1021/ol0629869. Org Lett. 2007. PMID: 17249805 Free PMC article.

2

Enantio- and diastereoselective synthesis of syn-beta-hydroxyallylsilanes via a chiral (Z)-gamma-silylallylboronate.

Lira R, Roush WR. Lira R, et al. Org Lett. 2007 Oct 11;9(21):4315-8. doi: 10.1021/ol7018746. Epub 2007 Sep 15. Org Lett. 2007. PMID: 17867698

3

Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane.

Kister J, DeBaillie AC, Lira R, Roush WR. Kister J, et al. Among authors: lira r. J Am Chem Soc. 2009 Oct 14;131(40):14174-5. doi: 10.1021/ja905494c. J Am Chem Soc. 2009. PMID: 19775159 Free PMC article.

4

Enantio- and diastereoselective synthesis of (E)-1,5-syn-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin.

Kister J, Nuhant P, Lira R, Sorg A, Roush WR. Kister J, et al. Among authors: lira r. Org Lett. 2011 Apr 1;13(7):1868-71. doi: 10.1021/ol2003836. Epub 2011 Mar 4. Org Lett. 2011. PMID: 21375316 Free PMC article.

5

Development of a Double Allylboration Reagent Targeting 1,5-syn-(E)-Diols: Application to the Synthesis of the C(23)-C(40) Fragment of Tetrafibricin.

Nuhant P, Kister J, Lira R, Sorg A, Roush WR. Nuhant P, et al. Among authors: lira r. Tetrahedron. 2011 Sep 2;67(35):6497-6512. doi: 10.1016/j.tet.2011.06.008. Tetrahedron. 2011. PMID: 21857752 Free PMC article.

6

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Chen YT, et al. Among authors: lira r. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18585034 Free PMC article.

7

Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.

Lee CW, Lira R, Dutra J, Ogilvie K, O'Neill BT, Brodney M, Helal C, Young J, Lachapelle E, Sakya S, Murray JC. Lee CW, et al. Among authors: lira r. J Org Chem. 2013 Mar 15;78(6):2661-9. doi: 10.1021/jo400016m. Epub 2013 Mar 4. J Org Chem. 2013. PMID: 23438191

8

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.

Doundoulakis T, Xiang AX, Lira R, Agrios KA, Webber SE, Sisson W, Aust RM, Shah AM, Showalter RE, Appleman JR, Simonsen KB. Doundoulakis T, et al. Among authors: lira r. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5667-72. doi: 10.1016/j.bmcl.2004.08.045. Bioorg Med Chem Lett. 2004. PMID: 15482944

9

Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.

Brodney MA, Beck EM, Butler CR, Barreiro G, Johnson EF, Riddell D, Parris K, Nolan CE, Fan Y, Atchison K, Gonzales C, Robshaw AE, Doran SD, Bundesmann MW, Buzon L, Dutra J, Henegar K, LaChapelle E, Hou X, Rogers BN, Pandit J, Lira R, Martinez-Alsina L, Mikochik P, Murray JC, Ogilvie K, Price L, Sakya SM, Yu A, Zhang Y, O'Neill BT. Brodney MA, et al. Among authors: lira r. J Med Chem. 2015 Apr 9;58(7):3223-52. doi: 10.1021/acs.jmedchem.5b00191. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25781223 Free PMC article.

10

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Lira R, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Vetelino BC, Xie L, Zhang L, Pustilnik LR, Wood KM, O'Donnell CJ. Pettersson M, et al. Among authors: lira r. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2906-11. doi: 10.1016/j.bmcl.2012.02.059. Epub 2012 Mar 1. Bioorg Med Chem Lett. 2012. PMID: 22429469

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