Walsh CT - Search Results

1

Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases.

Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. Yeh E, et al. Among authors: walsh ct. Biochemistry. 2007 Feb 6;46(5):1284-92. doi: 10.1021/bi0621213. Biochemistry. 2007. PMID: 17260957

2

Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

Yeh E, Cole LJ, Barr EW, Bollinger JM Jr, Ballou DP, Walsh CT. Yeh E, et al. Among authors: walsh ct. Biochemistry. 2006 Jun 27;45(25):7904-12. doi: 10.1021/bi060607d. Biochemistry. 2006. PMID: 16784243

3

The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction.

Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. Ryan KS, et al. Among authors: walsh ct. Biochemistry. 2008 Dec 23;47(51):13506-13. doi: 10.1021/bi801229w. Biochemistry. 2008. PMID: 19035832 Free PMC article.

4

Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase.

Setser JW, Heemstra JR Jr, Walsh CT, Drennan CL. Setser JW, et al. Among authors: walsh ct. Biochemistry. 2014 Sep 30;53(38):6063-77. doi: 10.1021/bi500655q. Epub 2014 Sep 16. Biochemistry. 2014. PMID: 25184411 Free PMC article.

5

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis.

Yeh E, Garneau S, Walsh CT. Yeh E, et al. Among authors: walsh ct. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3960-5. doi: 10.1073/pnas.0500755102. Epub 2005 Mar 2. Proc Natl Acad Sci U S A. 2005. PMID: 15743914 Free PMC article.

6

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.

Vaillancourt FH, Yeh E, Vosburg DA, O'Connor SE, Walsh CT. Vaillancourt FH, et al. Among authors: walsh ct. Nature. 2005 Aug 25;436(7054):1191-4. doi: 10.1038/nature03797. Nature. 2005. PMID: 16121186

7

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.

Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dorrestein PC, et al. Among authors: walsh ct. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13843-8. doi: 10.1073/pnas.0506964102. Epub 2005 Sep 14. Proc Natl Acad Sci U S A. 2005. PMID: 16162666 Free PMC article.

8

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis.

Blasiak LC, Vaillancourt FH, Walsh CT, Drennan CL. Blasiak LC, et al. Among authors: walsh ct. Nature. 2006 Mar 16;440(7082):368-71. doi: 10.1038/nature04544. Nature. 2006. PMID: 16541079

9

Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.

Lai JR, Koglin A, Walsh CT. Lai JR, et al. Among authors: walsh ct. Biochemistry. 2006 Dec 19;45(50):14869-79. doi: 10.1021/bi061979p. Biochemistry. 2006. PMID: 17154525 Review.

10

Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.

Kelly WL, Boyne MT 2nd, Yeh E, Vosburg DA, Galonić DP, Kelleher NL, Walsh CT. Kelly WL, et al. Among authors: walsh ct. Biochemistry. 2007 Jan 16;46(2):359-68. doi: 10.1021/bi061930j. Biochemistry. 2007. PMID: 17209546

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