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Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT. Parroche P, et al. Among authors: golenbock dt. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1919-24. doi: 10.1073/pnas.0608745104. Epub 2007 Jan 29. Proc Natl Acad Sci U S A. 2007. PMID: 17261807 Free PMC article.
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Among authors: golenbock dt. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5789-94. doi: 10.1073/pnas.0809742106. Epub 2009 Mar 18. Proc Natl Acad Sci U S A. 2009. PMID: 19297619 Free PMC article.
Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT. Sharma S, et al. Among authors: golenbock dt. Immunity. 2011 Aug 26;35(2):194-207. doi: 10.1016/j.immuni.2011.05.016. Epub 2011 Aug 4. Immunity. 2011. PMID: 21820332 Free PMC article.
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T. Latz E, et al. Among authors: golenbock dt. J Biol Chem. 2002 Dec 6;277(49):47834-43. doi: 10.1074/jbc.M207873200. Epub 2002 Sep 24. J Biol Chem. 2002. PMID: 12324469 Free article.
Receptor "cross talk" in innate immunity.
Latz E, Golenbock DT. Latz E, et al. Among authors: golenbock dt. J Clin Invest. 2003 Oct;112(8):1136-7. doi: 10.1172/JCI20040. J Clin Invest. 2003. PMID: 14561697 Free PMC article.
256 results