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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Wade JD, Barnham KJ. Tickler AK, et al. Among authors: tew dj. J Biol Chem. 2005 Apr 8;280(14):13355-63. doi: 10.1074/jbc.M414178200. Epub 2005 Jan 24. J Biol Chem. 2005. PMID: 15668252 Free article.
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, Lau TL, Tew DJ, Perez K, Wade JD, Bush AI, Drew SC, Separovic F, Masters CL, Cappai R, Barnham KJ. Smith DP, et al. Among authors: tew dj. J Biol Chem. 2006 Jun 2;281(22):15145-54. doi: 10.1074/jbc.M600417200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595673 Free article.
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Barnham KJ, Kenche VB, Ciccotosto GD, Smith DP, Tew DJ, Liu X, Perez K, Cranston GA, Johanssen TJ, Volitakis I, Bush AI, Masters CL, White AR, Smith JP, Cherny RA, Cappai R. Barnham KJ, et al. Among authors: tew dj. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6813-8. doi: 10.1073/pnas.0800712105. Epub 2008 May 7. Proc Natl Acad Sci U S A. 2008. PMID: 18463291 Free PMC article.
Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation.
Crouch PJ, Tew DJ, Du T, Nguyen DN, Caragounis A, Filiz G, Blake RE, Trounce IA, Soon CP, Laughton K, Perez KA, Li QX, Cherny RA, Masters CL, Barnham KJ, White AR. Crouch PJ, et al. Among authors: tew dj. J Neurochem. 2009 Mar;108(5):1198-207. doi: 10.1111/j.1471-4159.2009.05870.x. Epub 2009 Jan 7. J Neurochem. 2009. PMID: 19141082 Free article.
Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R. Ciccotosto GD, et al. Among authors: tew dj. Neurobiol Aging. 2011 Feb;32(2):235-48. doi: 10.1016/j.neurobiolaging.2009.02.018. Epub 2009 Mar 25. Neurobiol Aging. 2011. PMID: 19324459
31 results