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A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
Gandhi V, Kilpatrick JM, Plunkett W, Ayres M, Harman L, Du M, Bantia S, Davisson J, Wierda WG, Faderl S, Kantarjian H, Thomas D. Gandhi V, et al. Among authors: davisson j. Blood. 2005 Dec 15;106(13):4253-60. doi: 10.1182/blood-2005-03-1309. Epub 2005 Aug 30. Blood. 2005. PMID: 16131572 Free PMC article. Clinical Trial.
S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing.
Rayaprolu V, Miettinen HM, Baker W, Young VC, Fisher M, Mueller G, Rankin WO, Kelley JJ, Ratzan W, Leong LM, Davisson JA, Baker BJ, Kohout SC. Rayaprolu V, et al. Among authors: davisson ja. bioRxiv [Preprint]. 2024 Apr 9:2023.12.27.573443. doi: 10.1101/2023.12.27.573443. bioRxiv. 2024. Update in: J Gen Physiol. 2024 Jul 1;156(7):e202313467. doi: 10.1085/jgp.202313467 PMID: 38234747 Free PMC article. Updated. Preprint.
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